Reactome | ARID4B [nucleoplasm]

ARID4B [nucleoplasm]

Stable Identifier

R-HSA-2976647

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AT-rich interactive domain-containing protein 4B, ARI4B_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        ARID4B [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        ARID4B [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        ARID4B [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        ARID4B [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - SARS-CoV Infections (Homo sapiens)
    - Potential therapeutics for SARS (Homo sapiens)
      - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        ARID4B [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        ARID4B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q4LE39 ARID4B

Gene Names

ARID4B, BRCAA1, RBBP1L1, RBP1L1, SAP180

Chain

chain:1-1312

Reference Genes

BioGPS Gene:51742 ARID4B

COSMIC (genes):ARID4B ARID4B

CTD Gene:51742 ARID4B

dbSNP Gene:51742 ARID4B

ENSEMBL:ENSG00000054267 ARID4B

HGNC:15550 ARID4B

KEGG Gene (Homo sapiens):51742 ARID4B

Monarch:51742 ARID4B

NCBI Gene:51742 ARID4B

OMIM:609696 ARID4B

UCSC:Q4LE39 ARID4B

Reference Transcript

Other Identifiers

0001170136

0002810044

0106200739

11721879_s_at

11721880_s_at

11746691_s_at

11747219_a_at

16700737

221230_s_at

223111_x_at

2461785

2461787

2461788

2461789

2461790

2461791

2461793

2461797

2461801

2461806

2461811

2461815

2461816

2461822

2461823

2461827

2461828

2461829

2461831

2461834

2461837

2461838

2461839

2461844

2461848

2461849

2461850

2461851

2461852

2461865

2461866

2461867

2461868

2461869

2461877

2461878

2461879

47878_f_at

51742

55816_at

63394_at

63532_at

74178_at

7925201

A_23_P201951

A_24_P225308

GE54988

GO:0000976

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006325

GO:0006355

GO:0006357

GO:0008150

GO:0009058

GO:0034641

GO:0043226

GO:0051276

HMNXSV003026349

Hs.17428.0.S1_3p_s_at

ILMN_1761334

ILMN_2269564

ILMN_2362982

PH_hs_0001575

TC01006389.hg

g13518237_3p_s_at

Participates

as a component of

Inferred To

RSC9 [nucleoplasm] (Saccharomyces cerevisiae)

Arid4b [nucleoplasm] (Mus musculus)

Arid4b [nucleoplasm] (Rattus norvegicus)

Homologues of ARID4B [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of ARID4B [nucleoplasm] (Danio rerio)

Ghost homologue of ARID4B [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of ARID4B [nucleoplasm] (Xenopus tropicalis)

ARID4B [nucleoplasm] (Bos taurus)

ARID4B [nucleoplasm] (Canis familiaris)

ARID4B [nucleoplasm] (Sus scrofa)

htk [nucleoplasm] (Drosophila melanogaster)

sol1 [nucleoplasm] (Schizosaccharomyces pombe)

SWI1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_112739.2, NP_001193723.1, XP_011542514.1, NP_057458.4

OpenTargets

ENSG00000054267

GeneCards

Q4LE39

HPA

ENSG00000054267-ARID4B

Ensembl

ENST00000421364, ENSP00000394663, ENST00000366603, ENSP00000355562, ENST00000264183, ENSP00000264184, ENSP00000264183, ENSG00000054267, ENST00000349213

PRO

Q4LE39

Pharos - Targets

Q4LE39

GlyGen

Q4LE39

PDB

7DM4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14921 ETS1	2	ETS1 [nucleoplasm] (R-HSA-1629809) p-T38-ETS1 [nucleoplasm] (R-HSA-3132720)	0.524	2