Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ARHGEF3 [cytosol]
Stable Identifier
R-HSA-2976629
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 3, ARHG3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF3 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF3 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF3 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NR81 ARHGEF3
Gene Names
ARHGEF3
Chain
chain:1-526
Reference Genes
BioGPS Gene:50650 ARHGEF3
COSMIC (genes):ARHGEF3 ARHGEF3
CTD Gene:50650 ARHGEF3
dbSNP Gene:50650 ARHGEF3
ENSEMBL:ENSG00000163947 ARHGEF3
HGNC:683 ARHGEF3
KEGG:hsa:50650 ARHGEF3
Monarch:50650 ARHGEF3
NCBI Gene:50650 ARHGEF3
OMIM:612115 ARHGEF3
UCSC:Q9NR81 ARHGEF3
Reference Transcript
RefSeq:NM_001128615.1 ARHGEF3
RefSeq:NM_019555.2 ARHGEF3
RefSeq:NM_001128616.1 ARHGEF3
RefSeq:XM_005265187.3 ARHGEF3
RefSeq:XM_005265186.4 ARHGEF3
RefSeq:NM_001289698.1 ARHGEF3
Other Identifiers
11720860_s_at
11720861_a_at
11723491_a_at
11723492_a_at
16955291
218501_PM_at
218501_at
2677724
2677725
2677726
2677727
2677728
2677729
2677730
2677733
2677734
2677738
2677741
2677742
2677743
2677744
2677749
2677750
2677761
2677762
2677763
2677764
2677782
2677787
2677790
2677791
2677803
2677804
2677808
2677811
2677816
2677817
2677833
2677834
2677838
2677840
2677841
2677842
50650
51105_at
77800_at
8088247
A_23_P143885
GE62942
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0007266
GO:0035025
GO:0035556
GO:0051056
GO:0098772
HMNXSV003040611
ILMN_1781010
PH_hs_0002285
g9506400_3p_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Inferred To
Arhgef3 [cytosol]
(Mus musculus)
Arhgef3 [cytosol]
(Rattus norvegicus)
ARHGEF3 [cytosol]
(Bos taurus)
ARHGEF3 [cytosol]
(Canis familiaris)
ARHGEF3 [cytosol]
(Gallus gallus)
ARHGEF3 [cytosol]
(Sus scrofa)
arhgef3.2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_062455.1
,
XP_005265244.1
,
XP_005265243.1
,
NP_001122087.1
,
NP_001122088.1
,
NP_001276627.1
ENSEMBL
ENSP00000341071
,
ENSP00000410922
,
ENST00000296315
,
ENSP00000296315
,
ENST00000413728
,
ENST00000338458
OpenTargets
ENSG00000163947
HPA
ENSG00000163947-ARHGEF3
PRO
Q9NR81
Pharos - Targets
Q9NR81
HMDB Protein
HMDBP11512
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.83
8
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text