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APC [cytosol]
Stable Identifier
R-HSA-2976015
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Adenomatous polyposis coli protein, APC_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by GSK3beta mutants (Homo sapiens)
Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)
pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
APC [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase mediated cleavage of APC (Homo sapiens)
APC [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
APC is K63-polyubiquitinated (Homo sapiens)
APC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25054 APC
Gene Names
APC, DP2.5
Chain
initiator methionine:, chain:2-2843
Reference Genes
COSMIC (genes):APC APC
dbSNP Gene:324 APC
ENSEMBL:ENSG00000134982 APC
Participates
as a component of
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
as an input of
APC is K63-polyubiquitinated (Homo sapiens)
Caspase mediated cleavage of APC (Homo sapiens)
Other forms of this molecule
APC R213* [cytosol]
APC C1410* [cytosol]
APC K1310* [cytosol]
APC R499* [cytosol]
APC R1450* [cytosol]
APC G1357* [cytosol]
APC L1488* [cytosol]
APC S1400* [cytosol]
APC S1346* [cytosol]
APC R405* [cytosol]
APC S1281* [cytosol]
APC E1573* [cytosol]
APC R805* [cytosol]
APC R1386* [cytosol]
APC S1327* [cytosol]
APC E1209* [cytosol]
APC Q1469* [cytosol]
APC R564* [cytosol]
APC E1536* [cytosol]
APC G1288* [cytosol]
APC G1312* [cytosol]
APC R283* [cytosol]
APC Q1367* [cytosol]
APC E1353* [cytosol]
APC R332* [cytosol]
APC K993* [cytosol]
APC R876* [cytosol]
APC R302* [cytosol]
APC E1309* [cytosol]
APC Y935* [cytosol]
APC E1286* [cytosol]
APC Q1378* [cytosol]
APC R554* [cytosol]
APC S1356* [cytosol]
APC R232* [cytosol]
APC E1379* [cytosol]
APC E984* [cytosol]
APC R1114* [cytosol]
APC S1282* [cytosol]
APC Q1328* [cytosol]
APC E1295* [cytosol]
APC E1151* [cytosol]
APC E1322* [cytosol]
APC E1345* [cytosol]
APC K1308* [cytosol]
APC S1344* [cytosol]
APC E1577* [cytosol]
APC Q1127* [cytosol]
APC E1464* [cytosol]
APC E1317* [cytosol]
APC G1309Dfs*4 [cytosol]
APC W1049* [cytosol]
APC Q1429* [cytosol]
APC L1564* [cytosol]
APC Q1294* [cytosol]
APC K1363* [cytosol]
APC E1408* [cytosol]
APC E1284* [cytosol]
APC E1374* [cytosol]
APC Q767* [cytosol]
APC E941* [cytosol]
APC Q1303* [cytosol]
APC(778-2843) [cytosol]
APC(1-777) [cytosol]
K63polyUb-APC [cytosol]
p-ub-APC [cytosol]
APC [nucleoplasm]
APC E1554* [cytosol]
APC I1417 fs*2 [cytosol]
APC S811* [cytosol]
APC Q1338* [cytosol]
APC F1197* [cytosol]
APC E1544* [cytosol]
APC Q1406* [cytosol]
APC E1397* [cytosol]
APC E1451* [cytosol]
APC S1539* [cytosol]
APC S1392* [cytosol]
APC Q886* [cytosol]
APC Y1376* [cytosol]
APC G1412* [cytosol]
APC S1315* [cytosol]
APC S895* [cytosol]
APC E1306* [cytosol]
APC S943* [cytosol]
Inferred To
apr-1 [cytosol]
(Caenorhabditis elegans)
APC [cytosol]
(Bos taurus)
APC [cytosol]
(Canis familiaris)
APC [cytosol]
(Gallus gallus)
APC [cytosol]
(Sus scrofa)
apc [cytosol]
(Xenopus tropicalis)
Apc [cytosol]
(Drosophila melanogaster)
Apc [cytosol]
(Mus musculus)
Apc [cytosol]
(Rattus norvegicus)
Apc2 [cytosol]
(Drosophila melanogaster)
Homologues of APC [cytosol]
(Drosophila melanogaster)
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.962
22
UniProt:O15169 AXIN1
11
AXIN1 [cytosol]
(R-HSA-195249)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
0.845
17
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.825
6
UniProt:P49841 GSK3B
4
GSK3B [cytosol]
(R-HSA-2997551)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [nucleoplasm]
(R-HSA-2022823)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
0.816
6
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.802
6
UniProt:P49674 CSNK1E
2
CSNK1E [cytosol]
(R-HSA-205877)
CSNK1E [nucleoplasm]
(R-HSA-421306)
0.738
8
UniProt:Q5JTC6 AMER1
5
AMER1 R497* [cytosol]
(R-HSA-9663943)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 [cytosol]
(R-HSA-1504189)
0.723
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.697
5
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.669
4
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.668
9
UniProt:Q96N96 SPATA13
1
SPATA13 [cytosol]
(R-HSA-9690931)
0.667
5
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.667
4
UniProt:Q9NR80-3 ARHGEF4
0.646
5
UniProt:P35221 CTNNA1
2
CTNNA1 [plasma membrane]
(R-HSA-191735)
CTNNA1 [cytosol]
(R-HSA-191697)
0.64
3
UniProt:P14923 JUP
6
JUP [plasma membrane]
(R-HSA-437260)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [cytosol]
(R-HSA-201598)
0.64
3
UniProt:Q8N944 AMER3
0.631
8
UniProt:Q02248 Ctnnb1
14
Ctnnb1 [nucleoplasm]
(R-MMU-3451168)
Ctnnb1 [cytosol]
(R-MMU-448839)
Ctnnb1 [cytosol]
(R-MMU-202930)
Ctnnb1 [cytosol]
(R-MMU-202950)
Ctnnb1 [nucleoplasm]
(R-MMU-9735212)
Ctnnb1 [plasma membrane]
(R-MMU-9038440)
Ctnnb1 [plasma membrane]
(R-MMU-9761458)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942374)
beta-catenin [cytosol]
(R-MMU-206225)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942369)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942367)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942363)
phospho-Ctnnb1 [cytosol]
(R-MMU-3134933)
phospho-Ctnnb1 [nucleoplasm]
(R-MMU-3134926)
0.623
8
UniProt:O14640 DVL1
4
ub-DVL1 [cytosol]
(R-HSA-4641157)
DVL1 [cytosol]
(R-HSA-201687)
p-S-DVL1 [cytosol]
(R-HSA-201700)
pp-DVL1 [cytosol]
(R-HSA-3772396)
0.623
6
UniProt:Q12959 DLG1
4
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [plasma membrane]
(R-HSA-375977)
0.623
2
UniProt:Q96N96-1 SPATA13
0.619
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.615
3
UniProt:O14936 CASK
1
CASK [cytosol]
(R-HSA-373631)
0.59
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:O14641 DVL2
5
DVL2 [cytosol]
(R-HSA-201694)
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.564
2
UniProt:Q14114 LRP8
2
p-Y-LRP8 [plasma membrane]
(R-HSA-432136)
LRP8 [plasma membrane]
(R-HSA-432113)
0.558
2
UniProt:Q86T90 K1328
0.547
2
UniProt:O14513 NCKP5
0.547
2
UniProt:Q04695 KRT17
1
KRT17 [cytosol]
(R-HSA-201583)
0.547
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.536
2
UniProt:Q16204 CCDC6
0.527
4
UniProt:Q9NUP9 LIN7C
2
LIN7C [plasma membrane]
(R-HSA-5216165)
LIN7C [transport vesicle membrane]
(R-HSA-9610411)
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:Q9UI47 CTNA3
0.527
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.527
3
IntAct:EBI-6876712 CTNB1
0.499
6
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![APC [cytosol] icon](/icon/R-ICO-012434.svg){kind=icon}
