Reactome | NOTCH2 binds MDK

NOTCH2 binds MDK

Stable Identifier

R-HSA-2974737

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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MDK (Midkine, MK) is a secreted, heparin-binding growth factor that acts as a homodimer (Iwasaki et al. 1997). Both the full-length and the C-terminal region of MDK can bind the N-terminus of NOTCH2. In the presence of MDK, NICD2 accumulates in the nucleus in a dose-dependent fashion and epithelial-to-mesenchymal-transition (EMT) morphological changes are induced through a mechanism that has not been fully elucidated (Huang et al. 2008, Gungor et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
9384573	Solution structure of midkine, a new heparin-binding growth factor Iwasaki, W, Nagata, K, Hatanaka, H, Inui, T, Kimura, T, Muramatsu, T, Yoshida, K, Tasumi, M, Inagaki, F	EMBO J.	1997
18469519	Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes Huang, Y, Hoque, MO, Wu, F, Trink, B, Sidransky, D, Ratovitski, EA	Cell Cycle	2008
21632553	Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer Güngör, C, Zander, H, Effenberger, KE, Vashist, YK, Kalinina, T, Izbicki, JR, Yekebas, E, Bockhorn, M	Cancer Res.	2011