NOTCH2 binds MDK

Stable Identifier
Homo sapiens
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MDK (Midkine, MK) is a secreted, heparin-binding growth factor that acts as a homodimer (Iwasaki et al. 1997). Both the full-length and the C-terminal region of MDK can bind the N-terminus of NOTCH2. In the presence of MDK, NICD2 accumulates in the nucleus in a dose-dependent fashion and epithelial-to-mesenchymal-transition (EMT) morphological changes are induced through a mechanism that has not been fully elucidated (Huang et al. 2008, Gungor et al. 2011).

Literature References
PubMed ID Title Journal Year
9384573 Solution structure of midkine, a new heparin-binding growth factor

Hatanaka, H, Yoshida, K, Nagata, K, Inagaki, F, Inui, T, Muramatsu, T, Tasumi, M, Kimura, T, Iwasaki, W

EMBO J. 1997
18469519 Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

Huang, Y, Wu, F, Sidransky, D, Ratovitski, EA, Trink, B, Hoque, MO

Cell Cycle 2008
21632553 Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer

Izbicki, JR, Güngör, C, Kalinina, T, Vashist, YK, Bockhorn, M, Yekebas, E, Effenberger, KE, Zander, H

Cancer Res. 2011
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