POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter

Stable Identifier
R-HSA-2972975
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the SALL1 gene (Boyer et al. 2005, Yang et al. 2010) and activate expression (Babaie et al. 2007). SALL4 binds the SALL1 promoter and represses expression thus making SALL4 and POU5F1 antagonistic (Yang et al. 2010).

Literature References
PubMed ID Title Journal Year
20505821 A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells

Yang, J, Gao, C, Chai, L, Ma, Y

PLoS One 2010
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
22215994 Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development

Göke, J, Jung, M, Behrens, S, Chavez, L, O'Keeffe, S, Timmermann, B, Lehrach, H, Adjaye, J, Vingron, M

PLoS Comput. Biol. 2011
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
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