POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter

Stable Identifier
R-HSA-2972965
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the TSC22D1 gene (Boyer et al. 2005, Lister et al. 2009) and POU5F1 (Babaie et al. 2007, Greber et al. 2007, Kunarso et al. 2010), SOX2 (Greber et al. 2007), and NANOG (Greber et al. 2007) repress expression. TSC22D1 promotes TGFbeta-mediated cardiac myofibroblast differentiation (Yan et al. 2011), regulates hematopoietic cell proliferation (inferred from mouse in Yu et al. 2009), and associates with Smad4 to induce erythroid cell differentiation (inferred from mouse in Choi et al. 2005).

Literature References
PubMed ID Title Journal Year
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G

Nat. Genet. 2010
15881652 Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation

Choi, SJ, Moon, JH, Ahn, YW, Ahn, JH, Kim, DU, Han, TH

Mol. Cell. Biochem. 2005
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Greber, B, Lehrach, H, Adjaye, J

BMC Dev. Biol. 2007
19329776 TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

Yu, J, Ershler, M, Yu, L, Wei, M, Hackanson, B, Yokohama, A, Mitsui, T, Liu, C, Mao, H, Liu, S, Liu, Z, Trotta, R, Liu, CG, Liu, X, Huang, K, Visser, J, Marcucci, G, Plass, C, Belyavsky, AV, Caligiuri, MA

Blood 2009
21791611 TSC-22 promotes transforming growth factor ?-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity

Yan, X, Zhang, J, Pan, L, Wang, P, Xue, H, Zhang, L, Gao, X, Zhao, X, Ning, Y, Chen, YG

Mol. Cell. Biol. 2011
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
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