POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter

Stable Identifier
R-HSA-2972948
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter
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POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the GSC gene (Boyer et al. 2005, Lister et al. 2009) and POU5F1 represses expression (Babaie et al. 2007, Kunarso et al. 2010). GSC represses EVX1 and is required for formation of anterior streak-like progeny in response to Activin (Kalisz et al. 2012). As inferred from mouse, GSC is required for craniofacial development and rib development (Rivera-Perez et al. 1995).
Literature References
PubMed ID Title Journal Year
7555726 Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development

Gendron-Maguire, M, Behringer, RR, Mallo, M, Gridley, T, Rivera-Pérez, JA

Development 1995
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Thomson, JA, Nery, JR, Ye, Z, Pelizzola, M, Ruotti, V, Lister, R, Antosiewicz-Bourget, J, Tonti-Filippini, J, Edsall, L, Hawkins, RD, Lee, L, Ecker, JR, Dowen, RH, Hon, G, Ren, B, Ngo, QM, Stewart, R, Millar, AH

Nature 2009
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Ng, HH, Chan, YS, Bourque, G, Chia, NY, Hwang, C, Kunarso, G, Lu, X, Jeyakani, J

Nat. Genet. 2010
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
22178155 EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression

Serup, P, Winzi, M, Bisgaard, HC, Kalisz, M

Dev. Biol. 2012
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Adjaye, J, Kahlem, P, Lehrach, H, Vilo, J, Peterson, H, Chavez, L, Jung, M

PLoS One 2010
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
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Authored
May, B  (2013-01-03)
Reviewed
Wang, J  (2014-01-23)
Created
D'Eustachio, P  (2013-01-06)
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