POU5F1 (OCT4), STAT3 bind the SALL4 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

POU5F1 (OCT4) and STAT3 bind the promoter of the SALL4 gene and activate its transcription (Babaie et al. 2007, Tantin et al. 2008, Bard et al. 2009, Yang et al. 2010). SALL4, in turn, positively regulates POU5F1 expression (Yang et al. 2010). In mouse STAT3 is activated by Leukemia Inhibitory Factor (LIF), however LIF in humans does not have the same activity in promoting stem cell maintenance (Humphrey et al. 2004).

Literature References
PubMed ID Title Journal Year
18212089 High-throughput biochemical analysis of in vivo location data reveals novel distinct classes of POU5F1(Oct4)/DNA complexes

Gemberling, M, Tantin, D, Callister, C, Fairbrother, WG

Genome Res 2008
19151334 Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4

Gelebart, P, Lai, R, Ma, Y, Amin, HM, Bard, JD, Young, LC

FASEB J 2009
20505821 A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells

Chai, L, Yang, J, Gao, C, Ma, Y

PLoS One 2010
15277698 Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

Hayek, A, King, CC, Beattie, GM, Humphrey, RK, Lopez, AD, Bucay, N, Rose-John, S, Firpo, MT

Stem Cells 2004
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
Cite Us!