Reactome | SLC17A3-2 transports cytosolic urate to extracellular region

SLC17A3-2 transports cytosolic urate to extracellular region

Stable Identifier

R-HSA-2872497

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLC17A3-2 transports cytosolic urate to extracellular region

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Human serum urate levels are largely maintained by its reabsorption and secretion in the kidney. Loss of this maintenance can elevate urate levels leading to gout, hypertension, and various cardiovascular diseases. Renal urate reabsorption is controlled via two proximal tubular urate transporters; apical SLC22A12 (URAT1) and basolateral SLC2A9 (URATv1, GLUT9). On the other hand, urate secretion is mediated by the orphan sodium phosphate transporter 4 isoform 2 (SLC17A3, NPT4 isoform 2). It is mainly expressed at the apical side of renal tubules and functions as a voltage-driven urate transporter (Jutabha et al. 2010).

Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 4 (UAQTL4; MIM:612671). Excess serum urate (hyperuricemia) can lead to the development of gout, characterized by tissue deposition of monosodium urate crystals.

Literature References

PubMed ID	Title	Journal	Year
20810651	Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate Wempe, MF, Katada, T, Kimura, T, Fujita, T, Sakurai, H, Yamada, A, Shimada, H, Uchida, S, Yamanaka, H, Tomita, K, Endou, H, Yan, K, Jutabha, P, Fukutomi, T, Kitamura, K, Anzai, N, Urano, W, Seki, G, Taniguchi, A, Yamada, H, Moriyama, Y, Kaneko, S	J. Biol. Chem.	2010