SLC9B1/C2 exchange Na+ for H+

Stable Identifier
R-HSA-2872444
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, cytosol, plasma membrane
Locations in the PathwayBrowser
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SLC9B1/C2 exchange Na+ for H+
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The sodium/hydrogen exchanger 9B1 (SLC9B1 aka Na+/H+ exchanger like domain containing 1, NHEDC1) is specifically expressed on the plasma membrane of the testis and may be implicated in infertility (Ye et al. 2006). Sodium/hydrogen exchanger 9C2 (SLC9C2), also localized to the plasma membrane, may be involved in pH regulation although this protein has not been fully characterized.

Literature References
PubMed ID Title Journal Year
16850186 Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis

Ye, G, Chen, C, Han, D, Xiong, X, Kong, Y, Wan, B, Yu, L

Mol. Biol. Rep. 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
sodium:proton antiporter activity of SLC9B1/C2 [plasma membrane]
Physical Entity
SLC9B1/C2 [plasma membrane]
Activity
sodium:proton antiporter activity (0015385)
Orthologous Events
SLC9B1/C2 exchange Na+ for H+ (Bos taurus)
SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)
SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)
SLC9B1/C2 exchange Na+ for H+ (Danio rerio)
SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)
SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)
SLC9B1/C2 exchange Na+ for H+ (Mus musculus)
SLC9B1/C2 exchange Na+ for H+ (Rattus norvegicus)
SLC9B1/C2 exchange Na+ for H+ (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2012-12-21)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-21)
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