Reactome | EXOC7 [plasma membrane]

EXOC7 [plasma membrane]

Stable Identifier

R-HSA-2872288

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser for interactor UniProt:Q9WMX2 POLG

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External Reference Information

External Reference

UniProt:Q9UPT5 EXOC7

Gene Names

EXOC7, EXO70, KIAA1067

Chain

chain:1-735

Reference Genes

BioGPS Gene:23265 EXOC7

COSMIC (genes):EXOC7 EXOC7

CTD Gene:23265 EXOC7

dbSNP Gene:23265 EXOC7

ENSEMBL:ENSG00000182473 EXOC7

HGNC:23214 EXOC7

KEGG:hsa:23265 EXOC7

Monarch:23265 EXOC7

NCBI Gene:23265 EXOC7

OMIM:608163 EXOC7

UCSC:Q9UPT5 EXOC7

Reference Transcript

Participates

as a component of

Exocyst Complex [plasma membrane] (Homo sapiens)

as an input of

Exocyst complex formation (Homo sapiens)

Other forms of this molecule

EXOC7 [cytosol]

Inferred To

exoc-7 [plasma membrane] (Caenorhabditis elegans)

exoc7 [plasma membrane] (Dictyostelium discoideum)

Exoc7 [plasma membrane] (Mus musculus)

Exoc7 [plasma membrane] (Rattus norvegicus)

EXOC7 [plasma membrane] (Bos taurus)

EXOC7 [plasma membrane] (Canis familiaris)

EXOC7 [plasma membrane] (Gallus gallus)

Exo70 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001013861.1, NP_001138770.1, NP_056034.2, NP_001138769.1, NP_001138771.1, NP_001269242.1

OpenTargets

ENSG00000182473

ENSEMBL

ENSG00000182473, ENSP00000468404, ENSP00000404322, ENST00000411744, ENST00000589210, ENST00000335146, ENST00000634349, ENSP00000489266, ENSP00000334100, ENST00000332065, ENSP00000333806

GeneCards

EXOC7

HPA

ENSG00000182473-EXOC7

PRO

Q9UPT5

Pharos - Targets

Q9UPT5

GlyGen

Q9UPT5

HMDB Protein

HMDBP08386

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IY31 IFT20	3	IFT20 [cilium] (R-HSA-5617624) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [ciliary tip] (R-HSA-5625355)	0.743	5
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.725	4
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.725	5
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.666	4
UniProt:Q9BQD3 KXDL1			0.659	4
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.638	4
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.638	4
UniProt:Q9Y2D4 EXC6B			0.638	5
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.638	5
UniProt:A1L4H1 SSC5D	1	SSC5D [extracellular region] (R-HSA-8878615)	0.556	3
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.556	5
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.547	2
UniProt:Q9Y639 NPTN	1	NPTN [plasma membrane] (R-HSA-8856422)	0.527	2
UniProt:P21462 FPR1	4	FPR1 [plasma membrane] (R-HSA-375450) FPR1 [azurophil granule membrane] (R-HSA-6799143) FPR1 [secretory granule membrane] (R-HSA-6800929) FPR1 [ficolin-1-rich granule membrane] (R-HSA-6800878)	0.527	2
UniProt:P02724 GYPA	1	GYPA [plasma membrane] (R-HSA-8867204)	0.527	2
UniProt:O15218 GP182			0.527	3
UniProt:P25942 CD40			0.527	2
UniProt:P37198 NUP62	2	NUP62 [nuclear envelope] (R-HSA-157713) NUP62 [cytosol] (R-HSA-9634226)	0.527	3
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.527	2
UniProt:O60939 SCN2B	1	SCN2B [plasma membrane] (R-HSA-197905)	0.527	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	3
UniProt:Q9WMX2 POLG			0.499	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.463	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.463	2
UniProt:Q86VI4 LAP4B			0.463	2