Hydrolysis of internal thioester in C4b

Stable Identifier
R-HSA-2855047
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Hydrolysis of internal thioester in C4b
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Cleavage of C4 exposes a highly reactive thioester bond on the C4b molecule. The thioester bond is rapidly inactivated by hydrolysis if C4b does not bind to the target cell surface [Sepp A et al 1993].

Literature References
PubMed ID Title Journal Year
8495193 Covalent binding properties of the human complement protein C4 and hydrolysis rate of the internal thioester upon activation

Campbell, RD, Sepp, A, Law, SK, Anderson, MJ, Willis, AC, Dodds, AW

Protein Sci 1993
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Orthologous Events
Hydrolysis of C4b (Gallus gallus)
Hydrolysis of internal thioester in C4b (Bos taurus)
Hydrolysis of internal thioester in C4b (Caenorhabditis elegans)
Hydrolysis of internal thioester in C4b (Canis familiaris)
Hydrolysis of internal thioester in C4b (Danio rerio)
Hydrolysis of internal thioester in C4b (Drosophila melanogaster)
Hydrolysis of internal thioester in C4b (Gallus gallus)
Hydrolysis of internal thioester in C4b (Mus musculus)
Hydrolysis of internal thioester in C4b (Rattus norvegicus)
Hydrolysis of internal thioester in C4b (Sus scrofa)
Hydrolysis of internal thioester in C4b (Xenopus tropicalis)
Authored
Shamovsky, V  (2012-10-17)
Reviewed
Bradley, DT  (2013-05-28)
Created
Shamovsky, V  (2012-12-17)
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