Hydrolysis of internal thioester in C4b

Stable Identifier
R-HSA-2855047
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cleavage of C4 exposes a highly reactive thioester bond on the C4b molecule. The thioester bond is rapidly inactivated by hydrolysis if C4b does not bind to the target cell surface [Sepp A et al 1993].

Literature References
PubMed ID Title Journal Year
8495193 Covalent binding properties of the human complement protein C4 and hydrolysis rate of the internal thioester upon activation

Sepp, A, Dodds, AW, Anderson, MJ, Campbell, RD, Willis, AC, Law, SK

Protein Sci 1993
Participants
Participant Of
Orthologous Events
Authored
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Created