NOTCH1 PEST domain mutants bind JAG1

Stable Identifier
R-HSA-2768999
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH1 PEST domain mutants bind JAG1
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NOTCH1 PEST domain mutants are expected to bind to JAG1 ligand in an identical fashion to wild-type NOTCH1 (Li et al. 1998, Benedito et al. 2009).
Literature References
PubMed ID Title Journal Year
9462510 The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1

Friedman, C, Marcovina, S, Banta, AB, Torok-Storb, B, Deng, Y, Hood, L, Li, L, Trask, BJ, Graf, L, Milner, LA, Iwata, M

Immunity 1998
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Adams, S, Gossler, A, Adams, RH, Fruttiger, M, Roca, C, Sörensen, I

Cell 2009
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Normal reaction
NOTCH1 binds JAG1 (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST domain mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-12-11)
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