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SPP1 (osteopontin) binds CD44
Stable Identifier
R-HSA-2752115
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
Synonyms
Osteopontin binds CD44
ReviewStatus
5/5
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Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
SPP1 (osteopontin) binds CD44 (Homo sapiens)
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Osteopontin (SPP1) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins (Bellahcène et al. 2008). It is a highly phosphorylated sialoprotein and prominent component of the mineralized extracellular matrices of bones and teeth. It binds multiple integrins including alphaVbeta3, alphaVbeta1 and alphaVbeta5 (Liaw et al. 1995) alpha9beta1 (Smith et al. 1996, Yokosaki et al. 1999), alpha4beta1 (Bayliss et al. 1998) and the receptor CD44 (Weber et al. 1996, Katagiri et al. 1999). The SPP1–CD44 interaction may be important for colorectal cancer progression (Rao et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
8560266
Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
Ashkar, S
,
Cantor, H
,
Glimcher, MJ
,
Weber, GF
Science
1996
Participants
Input
CD44 [plasma membrane]
(Homo sapiens)
SPP1 [extracellular region]
(Homo sapiens)
Output
SPP1:CD44 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Integrin cell surface interactions (Homo sapiens)
Orthologous Events
SPP1 (osteopontin) binds CD44 (Bos taurus)
SPP1 (osteopontin) binds CD44 (Canis familiaris)
SPP1 (osteopontin) binds CD44 (Gallus gallus)
SPP1 (osteopontin) binds CD44 (Mus musculus)
SPP1 (osteopontin) binds CD44 (Rattus norvegicus)
SPP1 (osteopontin) binds CD44 (Sus scrofa)
Authored
Jupe, S (2012-07-31)
Reviewed
Ricard-Blum, S (2013-05-22)
Created
Jupe, S (2012-12-07)
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