Reactome | FXYD3 [plasma membrane]

FXYD3 [plasma membrane]

Stable Identifier

R-HSA-2752084

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FXYD domain-containing ion transport regulator 3, FXYD3_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        FXYDs [plasma membrane] (Homo sapiens)
        
        FXYD3 [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        FXYDs [plasma membrane] (Homo sapiens)
        
        FXYD3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14802 FXYD3

Gene Names

FXYD3, MAT8, PLML

Chain

signal peptide:1-20, chain:21-87

Reference Genes

BioGPS Gene:5349 FXYD3

COSMIC (genes):FXYD3 FXYD3

CTD Gene:5349 FXYD3

dbSNP Gene:5349 FXYD3

ENSEMBL:ENSG00000089356 FXYD3

HGNC:4027 FXYD3

KEGG:hsa:5349 FXYD3

Monarch:5349 FXYD3

NCBI Gene:5349 FXYD3

OMIM:604996 FXYD3

UCSC:Q14802 FXYD3

Reference Transcript

Participates

as a member of

FXYDs [plasma membrane] (Homo sapiens)

Inferred To

fxyd2 [plasma membrane] (Danio rerio)

fxyd7 [plasma membrane] (Danio rerio)

fxyd5 [plasma membrane] (Danio rerio)

Homologues of FXYD3 [plasma membrane] (Danio rerio)

fxyd3 [plasma membrane] (Danio rerio)

fxyd11 [plasma membrane] (Danio rerio)

Fxyd3 [plasma membrane] (Mus musculus)

Fxyd3 [plasma membrane] (Rattus norvegicus)

FXYD3 [plasma membrane] (Bos taurus)

FXYD3 [plasma membrane] (Canis familiaris)

Cross References

RefSeq

NP_001129480.1, NP_001129483.1, NP_001129481.1, XP_016882366.1, XP_016882367.1, NP_068710.1, NP_005962.1, XP_005259053.1, NP_001374279.1, NP_001129479.1, NP_001374282.1, NP_001374281.1, NP_001129482.1, NP_001129484.1, NP_001374278.1

Guide to Pharmacology - Targets

3153

OpenTargets

ENSG00000089356

ENSEMBL

ENSP00000474622, ENSP00000474526, ENST00000604255, ENST00000605552, ENST00000344013, ENSP00000473929, ENSG00000089356, ENST00000603181, ENST00000604621, ENST00000604404, ENSP00000339499, ENSP00000389770, ENSP00000474438, ENSP00000474851, ENSP00000474855, ENST00000346446, ENSP00000474055, ENSP00000328259, ENST00000605677, ENST00000435734, ENST00000603449

HPA

ENSG00000089356-FXYD3

GeneCards

FXYD3

PRO

Q14802

Pharos - Targets

Q14802

HMDB Protein

HMDBP08197

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43889 CREB3	7	CREB3(1-256) [nucleoplasm] (R-HSA-8874190) CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(292-371) [Golgi membrane] (R-HSA-8874173) CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165)	0.553	2

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