BESTs transport cytosolic HCO3- to extracellular region

Stable Identifier
R-HSA-2752067
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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BESTs transport cytosolic HCO3- to extracellular region
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Many Cl- channels such as CFTR, ClC, CaCC, and ligand-gated anion channels are permeable to bicarbonate (HCO3-) which is an important anion in the regulation of pH. Many tissues, including retinal pigment epithelium (RPE), utilize HCO3- transporters to mediate transport of HCO3-. Bestrophns 1-4 (BEST1-4, aka vitelliform macular dystrophy proteins) have high permeability to HCO3- (Hu & Hartzell 2008). Defective BEST1 may play a role in macular degeneration in the eye due to impaired HCO3- and Cl- conductance (Hu & Hartzell 2008).
Literature References
PubMed ID Title Journal Year
18400985 Bestrophin Cl- channels are highly permeable to HCO3-

Qu, Z, Hartzell, HC

Am. J. Physiol., Cell Physiol. 2008
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Output
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as an event of
Catalyst Activity

bicarbonate transmembrane transporter activity of BESTs [plasma membrane]

Physical Entity
BESTs [plasma membrane] (Homo sapiens)
Activity
bicarbonate transmembrane transporter activity (GO:0015106)
Orthologous Events
BESTs transport cytosolic HCO3- to extracellular region (Bos taurus)
BESTs transport cytosolic HCO3- to extracellular region (Caenorhabditis elegans)
BESTs transport cytosolic HCO3- to extracellular region (Canis familiaris)
BESTs transport cytosolic HCO3- to extracellular region (Danio rerio)
BESTs transport cytosolic HCO3- to extracellular region (Drosophila melanogaster)
BESTs transport cytosolic HCO3- to extracellular region (Gallus gallus)
BESTs transport cytosolic HCO3- to extracellular region (Mus musculus)
BESTs transport cytosolic HCO3- to extracellular region (Rattus norvegicus)
BESTs transport cytosolic HCO3- to extracellular region (Sus scrofa)
BESTs transport cytosolic HCO3- to extracellular region (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2012-12-07)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-07)
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