Reactome | TTYH1 transports cytosolic Cl- to extracellular region

TTYH1 transports cytosolic Cl- to extracellular region

Stable Identifier

R-HSA-2744349

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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TTYH1 transports cytosolic Cl- to extracellular region

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Protein tweety homolog 1 (TTYH1) has 5 isoforms. Isoform 3 (Campbell et al. 2000) mediates the Ca+-independent efflux of Cl- across plasma membranes (Suzuki & Mizuno 2004, Suzuki 2006).

Literature References

PubMed ID	Title	Journal	Year
10950931	Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins Suzuki, Y, Young, IG, Hida, M, Kamei, M, Campbell, HD, Sugano, S, Sutherland, GR, Claudianos, C, Woollatt, E	Genomics	2000
15010458	A novel human Cl(-) channel family related to Drosophila flightless locus Mizuno, A, Suzuki, M	J. Biol. Chem.	2004
16219661	The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels Suzuki, M	Exp. Physiol.	2006