Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants

Stable Identifier
R-HSA-2737728
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants has not been investigated but is assumed to occur based on the behavior of the wild-type NOTCH1 (Lai et al. 2001, Itoh et al. 2003, Koo et al. 2005, Lai et al. 2005, Le Borgne et al. 2005, Pistouli et al. 2005, Song et al. 2006, Koo et al. 2007, Koutelou et al. 2008).

Literature References
PubMed ID Title Journal Year
15760269 Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

Le Borgne, R, Remaud, S, Hamel, S, Schweisguth, F

PLoS Biol 2005
16093323 The interplay between DSL proteins and ubiquitin ligases in Notch signaling

Pitsouli, C, Delidakis, C

Development 2005
18043734 An obligatory role of mind bomb-1 in notch signaling of mammalian development

Koo, BK, Yoon, MJ, Yoon, KJ, Im, SK, Kim, YY, Kim, CH, Suh, PG, Jan, YN, Kong, YY

PLoS One 2007
15824097 Mind bomb-2 is an E3 ligase for Notch ligand

Koo, BK, Yoon, KJ, Yoo, KW, Lim, HS, Song, R, So, JH, Kim, CH, Kong, YY

J Biol Chem 2005
11740940 Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

Lai, EC, Deblandre, GA, Kintner, C, Rubin, GM

Dev Cell 2001
15829515 The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

Lai, EC, Roegiers, F, Qin, X, Jan, YN, Rubin, GM

Development 2005
17003037 Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1

Song, R, Koo, BK, Yoon, KJ, Yoon, MJ, Yoo, KW, Kim, HT, Oh, HJ, Kim, YY, Han, JK, Kim, CH, Kong, YY

J Biol Chem 2006
12530964 Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

Itoh, M, Kim, CH, Palardy, G, Oda, T, Jiang, YJ, Maust, D, Yeo, SY, Lorick, K, Wright, GJ, Ariza-McNaughton, L, Weissman, AM, Lewis, J, Chandrasekharappa, SC, Chitnis, AB

Dev Cell 2003
18077452 Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1

Koutelou, E, Sato, S, Tomomori-Sato, C, Florens, LA, Swanson, SK, Washburn, MP, Kokkinaki, M, Conaway, RC, Conaway, JW, Moschonas, NK

J Biol Chem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of MIB/NEURL [cytosol]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created