Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants

Stable Identifier
Reaction [transition]
Homo sapiens
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Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants has not been investigated but is assumed to occur based on the behavior of the wild-type NOTCH1 (Lai et al. 2001, Itoh et al. 2003, Koo et al. 2005, Lai et al. 2005, Le Borgne et al. 2005, Pistouli et al. 2005, Song et al. 2006, Koo et al. 2007, Koutelou et al. 2008).
Literature References
PubMed ID Title Journal Year
16093323 The interplay between DSL proteins and ubiquitin ligases in Notch signaling

Delidakis, C, Pitsouli, C

Development 2005
15760269 Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

Remaud, S, Hamel, S, Schweisguth, F, Le Borgne, R

PLoS Biol 2005
18043734 An obligatory role of mind bomb-1 in notch signaling of mammalian development

Kim, CH, Kim, YY, Yoon, MJ, Koo, BK, Suh, PG, Im, SK, Jan, YN, Kong, YY, Yoon, KJ

PLoS One 2007
15824097 Mind bomb-2 is an E3 ligase for Notch ligand

Kim, CH, Yoo, KW, Koo, BK, Song, R, So, JH, Kong, YY, Lim, HS, Yoon, KJ

J Biol Chem 2005
11740940 Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

Kintner, C, Rubin, GM, Deblandre, GA, Lai, EC

Dev Cell 2001
15829515 The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

Roegiers, F, Jan, YN, Rubin, GM, Lai, EC, Qin, X

Development 2005
17003037 Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1

Kim, CH, Kim, YY, Yoo, KW, Yoon, MJ, Koo, BK, Song, R, Kim, HT, Han, JK, Oh, HJ, Kong, YY, Yoon, KJ

J Biol Chem 2006
12530964 Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

Kim, CH, Ariza-McNaughton, L, Maust, D, Itoh, M, Jiang, YJ, Lorick, K, Wright, GJ, Yeo, SY, Weissman, AM, Chitnis, AB, Chandrasekharappa, SC, Lewis, J, Palardy, G, Oda, T

Dev Cell 2003
18077452 Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1

Washburn, MP, Swanson, SK, Moschonas, NK, Tomomori-Sato, C, Koutelou, E, Kokkinaki, M, Florens, LA, Conaway, JW, Sato, S, Conaway, RC

J Biol Chem 2008
Catalyst Activity

ubiquitin-protein transferase activity of MIB/NEURL [cytosol]

Normal reaction
Functional status

Gain of function of DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
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