Reactome | Recruitment of VAV to p-SLP-76

Recruitment of VAV to p-SLP-76

Stable Identifier

R-HSA-2730892

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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VAV an activator of RAC-GTPases, is redistributed to plasma membrane and is phosphorylated following engagement of FCERI. Phosphorylated SLP-76 tyrosines Y113 and Y128 (112Y and 128Y in mouse) provide binding sites for the SH2 domains of VAV. The binding of VAV to these phosphotyrosine residues may link SLP-76 to the Jun amino-terminal kinase (JNK) pathway and the actin cytoskeleton (Kettner et al. 2003).
In addition to its known role as guanine nucleotide exchange factor (GEF), VAV also modulates cytokine production in mast cells. VAV1-deficient bone marrow-derived mast cells exhibited reduced degranulation and cytokine production and calcium release in addition of reduced activation of c-Jun NH2-terminal kinase 1 (JNK1), although tyrosine phosphorylation of FCERI, SYK and LAT was normal (Manetz et al. 2001, Arudchandran et al. 2000, Song et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10395673	Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway Song, JS, Haleem-Smith, H, Arudchandran, R, Gomez, J, Scott, PM, Mill, JF, Tan, TH, Rivera, J	J. Immunol.	1999
11340169	Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells Manetz, TS, Gonzalez-Espinosa, C, Arudchandran, R, Xirasagar, S, Tybulewicz, V, Rivera, J	Mol. Cell. Biol.	2001
8673706	Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation Wu, J, Motto, DG, Koretzky, GA, Weiss, A	Immunity	1996