Reactome | Phosphorylation of NTAL by p-SYK/Lyn

Phosphorylation of NTAL by p-SYK/Lyn

Stable Identifier

R-HSA-2730884

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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NTAL and LAT play complementary roles in the positive regulation of FCERI-mediated degranulation. Upon FCERI aggregation NTAL is phosphorylated by LYN, SYK and KIT on different tyrosines. Phosphorylated NTAL likely contributes to the activation of mast cells by providing docking sites for the recruitment of critical signaling molecules into the lipid raft. There are about ten tyrosines in LAT2 of which five tyrosines principally phosphorylated by SYK are recognised as putative GRB2-binding sites, being part of a YXN motif, whereas LYN and KIT phosphorylate both tyrosines contained in the YXN motifs as well as tyrosines outside of the YXN motifs (Iwaki et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
15010370	NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation Tkaczyk, C, Horejsí, V, Iwaki, S, Dráber, P, Samelson, LE, Satterthwaite, AB, Nahm, DH, Metcalfe, DD, Gilfillan, AM	Blood	2004
17993265	Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells Iwaki, S, Spicka, J, Tkaczyk, C, Jensen, BM, Furumoto, Y, Charles, N, Kovarova, M, Rivera, J, Horejsí, V, Metcalfe, DD, Gilfillan, AM	Cell. Signal.	2008