Phosphorylation of PIP2 to PIP3 by PI3K

Stable Identifier
R-HSA-2730870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of PIP2 to PIP3 by PI3K
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PI3K catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-triphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and AKT.

Literature References
PubMed ID Title Journal Year
2833705 Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

Downes, CP, Cantley, LC, Keeler, M, Whitman, M, Keller, T

Nature 1988
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane]

Physical Entity
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
Cross References
Rhea
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
Cite Us!