Reactome | Recruitment of TRAF6 to CBM complex by binding to MALT1

Recruitment of TRAF6 to CBM complex by binding to MALT1

Stable Identifier

R-HSA-2730864

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Recruitment of TRAF6 to CBM complex by binding to MALT1

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TRAF6 is a ubiquitin ligase that plays a central role in the IKK-dependent canonical NF-kB pathway. It is recruited to the CBM complex by binding to MALT1. The MALT1 C-terminal Ig domain and extension contain two binding motifs for TRAF6 (Noels et al 2007). After oligomerzation TRAF6, together with Ubc13/Uev1A, activates TAK1 and IKK. It also acts as an E3 ligase for MALT1 and mediates lysine 63-linked ubiquitination (Oeckinghaus et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
18772140	TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation Yang, YJ, Chen, W, Carrigan, SO, Chen, WM, Roth, K, Akiyama, T, Inoue, J, Marshall, JS, Berman, JN, Lin, TJ	J. Biol. Chem.	2008
17948050	Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation Oeckinghaus, A, Wegener, E, Welteke, V, Ferch, U, Arslan, SC, Ruland, J, Scheidereit, C, Krappmann, D	EMBO J.	2007