Autophosphorylation of LYN kinase

Stable Identifier
R-HSA-2730862
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Autophosphorylation of LYN kinase
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LYN localized in lipid rafts undergoes an intermolecular autophosphorylation at tyrosine 396. This residue is present in the activation loop, and its phosphorylation promotes LYN kinase activity.

Literature References
PubMed ID Title Journal Year
9477973 Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity

Donella-Deana, A, Cesaro, L, Ruzzene, M, Brunati, AM, Marin, O, Pinna, LA

Biochemistry 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LYN [plasma membrane]
Physical Entity
LYN [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Autophosphorylation of LYN kinase (Bos taurus)
Autophosphorylation of LYN kinase (Caenorhabditis elegans)
Autophosphorylation of LYN kinase (Canis familiaris)
Autophosphorylation of LYN kinase (Gallus gallus)
Autophosphorylation of LYN kinase (Mus musculus)
Autophosphorylation of LYN kinase (Rattus norvegicus)
Autophosphorylation of LYN kinase (Sus scrofa)
Autophosphorylation of LYN kinase (Xenopus tropicalis)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)