Reactome | Autophosphorylation of BTK/ITK

Autophosphorylation of BTK/ITK

Stable Identifier

R-HSA-2730858

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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After initial phosphorylation by SFK's, subsequently Y223 (Y180 in ITK and Y206 in TEC) in the SH3 domain of BTK is autophosphorylated, which may prevent inhibitory intramolecular interactions (Nore et al. 2003, Joseph et al. 2007, Park et al. 1996)

Literature References

PubMed ID	Title	Journal	Year
7518558	Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking Kawakami, Y, Yao, L, Miura, T, Tsukada, S, Witte, ON, Kawakami, T	Mol. Cell. Biol.	1994
12573241	Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases Nore, BF, Mattsson, PT, Antonsson, P, Bäckesjö, CM, Westlund, A, Lennartsson, J, Hansson, H, Löw, P, Rönnstrand, L, Smith, CI	Biochim. Biophys. Acta	2003
8629002	Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases Rawlings, DJ, Scharenberg, AM, Park, H, Wahl, MI, Lin, S, Kato, RM, Fluckiger, AC, Witte, ON, Kinet, JP	Science	1996
8630736	Regulation of Btk function by a major autophosphorylation site within the SH3 domain Park, H, Wahl, MI, Afar, DE, Turck, CW, Rawlings, DJ, Tam, C, Scharenberg, AM, Kinet, JP, Witte, ON	Immunity	1996