After initial phosphorylation by SFK's, subsequently Y223 (Y180 in ITK and Y206 in TEC) in the SH3 domain of BTK is autophosphorylated, which may prevent inhibitory intramolecular interactions (Nore et al. 2003, Joseph et al. 2007, Park et al. 1996)
Kawakami, Y, Yao, L, Miura, T, Tsukada, S, Witte, ON, Kawakami, T
Nore, BF, Mattsson, PT, Antonsson, P, Bäckesjö, CM, Westlund, A, Lennartsson, J, Hansson, H, Löw, P, Rönnstrand, L, Smith, CI
Rawlings, DJ, Scharenberg, AM, Park, H, Wahl, MI, Lin, S, Kato, RM, Fluckiger, AC, Witte, ON, Kinet, JP
Park, H, Wahl, MI, Afar, DE, Turck, CW, Rawlings, DJ, Tam, C, Scharenberg, AM, Kinet, JP, Witte, ON
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