Autophosphorylation of BTK/ITK

Stable Identifier
R-HSA-2730858
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After initial phosphorylation by SFK's, subsequently Y223 (Y180 in ITK and Y206 in TEC) in the SH3 domain of BTK is autophosphorylated, which may prevent inhibitory intramolecular interactions (Nore et al. 2003, Joseph et al. 2007, Park et al. 1996)

Literature References
PubMed ID Title Journal Year
12573241 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases

Bäckesjö, CM, Nore, BF, Smith, CI, Mattsson, PT, Hansson, H, Westlund, A, Antonsson, P, Rönnstrand, L, Lennartsson, J, Löw, P

Biochim. Biophys. Acta 2003
7518558 Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

Miura, T, Tsukada, S, Kawakami, T, Witte, ON, Yao, L, Kawakami, Y

Mol. Cell. Biol. 1994
8629002 Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

Park, H, Witte, ON, Kato, RM, Lin, S, Kinet, JP, Fluckiger, AC, Scharenberg, AM, Wahl, MI, Rawlings, DJ

Science 1996
8630736 Regulation of Btk function by a major autophosphorylation site within the SH3 domain

Park, H, Turck, CW, Witte, ON, Kinet, JP, Scharenberg, AM, Tam, C, Wahl, MI, Rawlings, DJ, Afar, DE

Immunity 1996
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!