Reactome | Phosphorylation of LAT by p-SYK

Phosphorylation of LAT by p-SYK

Stable Identifier

R-HSA-2730843

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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LAT is palmitoylated and membrane-associated adaptor protein. It rapidly becomes tyrosine-phosphorylated upon receptor engagement. LAT has nine conserved tyrosine residues of which five have been shown to undergo phosphorylation (Y127, Y132, Y171, Y191 and Y226). Src family kinases, SYK and ZAP-70 efficiently phosphorylate LAT on these tyrosine residues (Jiang & Cheng 2007, Paz et al. 2001). Phosphorylation of LAT creates binding sites for the Src homology 2 (SH2) domain proteins PLC-gamma1, GRB2 and GADS, which indirectly bind SOS, VAV, SLP-76 and ITK (Wange 2000).

Literature References

PubMed ID	Title	Journal	Year
10072481	Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity Samelson, LE, Irvin, BJ, Abraham, RT, Dick, CJ, Leibson, PJ, Billadeau, DD, Zhang, W, Jevremovic, D, Schoon, RA	J. Immunol.	1999
11368773	Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells Abo, A, Wang, S, Lu, X, Paz, PE, Stokoe, D, Clarke, H	Biochem. J.	2001
16938345	Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes Jiang, Y, Cheng, H	Leuk Res	2007