Recruitment of GRB2:SOS to p-10Y-NTAL

Stable Identifier
R-HSA-2730837
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Recruitment of GRB2:SOS to p-10Y-NTAL
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Upon phosphorylation NATL/LAT2 recruits GRB2:SOS complex into the receptor-signaling complex. Residues Y95, Y118, Y136, Y193, Y233 are the putative GRB2-binding sites on NTAL (Iwaki et al. 2007).

Literature References
PubMed ID Title Journal Year
17993265 Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

Iwaki, S, Spicka, J, Tkaczyk, C, Jensen, BM, Furumoto, Y, Charles, N, Kovarova, M, Rivera, J, Horejsí, V, Metcalfe, DD, Gilfillan, AM

Cell. Signal. 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)
Recruitment of GRB2:SOS to p-10Y-NTAL (Canis familiaris)
Recruitment of GRB2:SOS to p-10Y-NTAL (Gallus gallus)
Recruitment of GRB2:SOS to p-10Y-NTAL (Mus musculus)
Recruitment of GRB2:SOS to p-10Y-NTAL (Rattus norvegicus)
Recruitment of GRB2:SOS to p-10Y-NTAL (Sus scrofa)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)