Reactome | Autophosphorylation of PKC-theta

Autophosphorylation of PKC-theta

Stable Identifier

R-HSA-2730835

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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T219, T538 at the activation loop, S676 at the turn motif and S695 at the hydrophobic motif are autophosphorylated in cis-maanner. Posphorylation of T538 is critical for kinase activation and it stabilises the open active conformation. Some studies suggest the involvement of PDK1 (3-phosphoinositide-dependent protein kinase 1) and GLK kinases in the phosphorylation T538.

Literature References

PubMed ID	Title	Journal	Year
22798961	Regulation of PKC-? function by phosphorylation in T cell receptor signaling Wang, X, Chuang, HC, Li, JP, Tan, TH	Front Immunol	2012
11772397	Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction Liu, Y, Graham, C, Li, A, Fisher, RJ, Shaw, S	Biochem. J.	2002
16252004	Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes Thuille, N, Heit, I, Fresser, F, Krumböck, N, Bauer, B, Leuthaeusser, S, Dammeier, S, Graham, C, Copeland, TD, Shaw, S, Baier, G	EMBO J.	2005