Autophosphorylation of PKC-theta

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

T219, T538 at the activation loop, S676 at the turn motif and S695 at the hydrophobic motif are autophosphorylated in cis-maanner. Posphorylation of T538 is critical for kinase activation and it stabilises the open active conformation. Some studies suggest the involvement of PDK1 (3-phosphoinositide-dependent protein kinase 1) and GLK kinases in the phosphorylation T538.

Literature References
PubMed ID Title Journal Year
22798961 Regulation of PKC-? function by phosphorylation in T cell receptor signaling

Tan, TH, Chuang, HC, Wang, X, Li, JP

Front Immunol 2012
11772397 Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction

Li, A, Liu, Y, Shaw, S, Graham, C, Fisher, RJ

Biochem. J. 2002
16252004 Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes

Baier, G, Bauer, B, Fresser, F, Heit, I, Dammeier, S, Copeland, TD, Graham, C, Thuille, N, Shaw, S, Leuthaeusser, S, Krumböck, N

EMBO J. 2005
Orthologous Events
Cite Us!