Reactome | NOTCH1 I1616T fragment [extracellular region]

NOTCH1 I1616T fragment [extracellular region]

Stable Identifier

R-HSA-2730746

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by NOTCH1 in Cancer (Homo sapiens)
    - Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
      - Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
        
        NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)
        
        NOTCH1 HD domain mutant fragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 I1616T fragment [extracellular region] (Homo sapiens)
        
        Ub-DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region] (Homo sapiens)
        
        DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region] (Homo sapiens)
        
        DLL1:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 I1616T fragment [extracellular region] (Homo sapiens)
        
        DLL4:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 I1616T fragment [extracellular region] (Homo sapiens)
        
        JAG1:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 I1616T fragment [extracellular region] (Homo sapiens)
        
        JAG2:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
        
        NOTCH1 I1616T fragment [extracellular region] (Homo sapiens)

Participants

components

Participates

as a member of

NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia	DOID:5603

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