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Ub-SCNN1A [plasma membrane]
Stable Identifier
R-HSA-2684930
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Amiloride-sensitive sodium channel subunit alpha, SCNNA_HUMAN, Ubiquitinated-SCNN1A
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)
Ub-SCNN channels [plasma membrane] (Homo sapiens)
Ub-SCNN1A/SCNN1D [plasma membrane] (Homo sapiens)
Ub-SCNN1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P37088 SCNN1A
Gene Names
SCNN1A, SCNN1
Chain
chain:1-669
Reference Genes
BioGPS Gene:6337 SCNN1A
COSMIC (genes):SCNN1A SCNN1A
CTD Gene:6337 SCNN1A
dbSNP Gene:6337 SCNN1A
ENSEMBL:ENSG00000111319 SCNN1A
HGNC:10599 SCNN1A
KEGG:hsa:6337 SCNN1A
Monarch:6337 SCNN1A
NCBI Gene:6337 SCNN1A
OMIM:600228 SCNN1A
UCSC:P37088 SCNN1A
Reference Transcript
RefSeq:NM_001159575.1 SCNN1A
RefSeq:NM_001038.5 SCNN1A
RefSeq:NM_001159576.1 SCNN1A
Other Identifiers
11748741_a_at
11755282_a_at
16760350
203453_PM_at
203453_at
215026_PM_x_at
215026_x_at
217264_PM_s_at
217264_s_at
3441886
3441887
3441888
3441889
3441890
3441891
3441892
3441893
3441895
3441896
3441897
3441898
3441899
3441900
3441901
3441902
3441904
3441905
3441906
3441907
3441909
3441910
3441911
3441912
3441913
3441915
3441916
35207_at
6337
7960529
A_23_P128323
GE60015
GO:0001669
GO:0005215
GO:0005272
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005929
GO:0006814
GO:0006883
GO:0008217
GO:0009897
GO:0015280
GO:0016020
GO:0016324
GO:0031410
GO:0031514
GO:0034220
GO:0034706
GO:0035725
GO:0043226
GO:0050699
GO:0050877
GO:0050891
GO:0050909
GO:0050914
GO:0050915
GO:0055078
GO:0055085
GO:0060170
GO:0070062
GO:0071468
GO:0097228
GO:0098662
GO:0098719
GO:1904045
GO:1904117
HMNXSV003022170
Hs.2794.1.S1_3p_x_at
Hs.2794.2.S1_3p_a_at
Hs.2794.2.S1_3p_x_at
ILMN_1713995
PH_hs_0021944
TC12001136.hg
X76180_at
g4506814_3p_at
Participates
as a member of
Ub-SCNN1A/SCNN1D [plasma membrane] (Homo sapiens)
Other forms of this molecule
SCNN1A [plasma membrane]
Inferred To
del-3 [plasma membrane]
(Caenorhabditis elegans)
SCNN1A [plasma membrane]
(Bos taurus)
SCNN1A [plasma membrane]
(Canis familiaris)
SCNN1A [plasma membrane]
(Sus scrofa)
egas-3 [plasma membrane]
(Caenorhabditis elegans)
del-6 [plasma membrane]
(Caenorhabditis elegans)
asic-1 [plasma membrane]
(Caenorhabditis elegans)
egas-1 [plasma membrane]
(Caenorhabditis elegans)
scnn1a [plasma membrane]
(Xenopus tropicalis)
Homologues of Ub-SCNN1A [plasma membrane]
(Caenorhabditis elegans)
Scnn1a [plasma membrane]
(Mus musculus)
Scnn1a [plasma membrane]
(Rattus norvegicus)
asic-2 [plasma membrane]
(Caenorhabditis elegans)
degt-1 [plasma membrane]
(Caenorhabditis elegans)
egas-4 [plasma membrane]
(Caenorhabditis elegans)
unc-8 [plasma membrane]
(Caenorhabditis elegans)
mec-10 [plasma membrane]
(Caenorhabditis elegans)
unc-105 [plasma membrane]
(Caenorhabditis elegans)
deg-1 [plasma membrane]
(Caenorhabditis elegans)
Ub-SCNN1A [plasma membrane]
(Gallus gallus)
egas-2 [plasma membrane]
(Caenorhabditis elegans)
mec-4 [plasma membrane]
(Caenorhabditis elegans)
del-1 [plasma membrane]
(Caenorhabditis elegans)
del-4 [plasma membrane]
(Caenorhabditis elegans)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin (linkage unknown) [plasma membrane]) at unknown position
Modification
polyubiquitin (linkage unknown) [plasma membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ZINC - World Drugs
SCNNA_HUMAN
Guide to Pharmacology - Targets
738
ENSEMBL
ENSP00000438739
,
ENSP00000353292
,
ENSP00000228916
,
ENST00000543768
,
ENST00000360168
,
ENST00000228916
OpenTargets
ENSG00000111319
ZINC - FDA approved
SCNNA_HUMAN
ZINC - Substances
SCNNA_HUMAN
ZINC target
P37088
PRO
P37088
GlyGen
P37088
PDB
6BQN
,
6WTH
,
2M3O
HPA
ENSG00000111319-SCNN1A
Pharos - Targets
P37088
Orphanet
SCNN1A
ZINC - Predictions - Purchasable
SCNNA_HUMAN
HMDB Protein
HMDBP02267
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46934 NEDD4
1
NEDD4 [cytosol]
(R-HSA-975992)
0.683
3
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