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EFNA1 [plasma membrane]
Stable Identifier
R-HSA-2682339
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin-A1, EFNA1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
ADAM10 cleaves EFNAs (Homo sapiens)
EPHAs:EFNAs:ADAM10 [plasma membrane] (Homo sapiens)
EFNAs:ADAM10 [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPHA binds TIAM1 (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
SFKs phosphorylate VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
p-EPHs bind VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPH:EFN dimers tetramerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHA:EFNA dimers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPH:EFN tetramers oligomerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHA:EFNA dimers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
NGEF binds EPHA (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
SFKs phosphorylate NGEF (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPHAs bind EFNAs (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EFNAs [plasma membrane] (Homo sapiens)
EFNA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20827 EFNA1
Gene Names
EFNA1, EPLG1, LERK1, TNFAIP4
Chain
signal peptide:1-18, chain:19-182, chain:19-, propeptide:183-205
Reference Genes
BioGPS Gene:1942 EFNA1
COSMIC (genes):EFNA1 EFNA1
CTD Gene:1942 EFNA1
dbSNP Gene:1942 EFNA1
ENSEMBL:ENSG00000169242 EFNA1
HGNC:3221 EFNA1
KEGG:hsa:1942 EFNA1
Monarch:1942 EFNA1
NCBI Gene:1942 EFNA1
OMIM:191164 EFNA1
UCSC:P20827 EFNA1
Reference Transcript
RefSeq:NM_004428.2 EFNA1
RefSeq:NM_182685.1 EFNA1
Other Identifiers
11716341_s_at
11754106_a_at
16671642
1942
202023_PM_at
202023_at
2360679
2360680
2360682
2360683
2360684
2360686
2360687
2360688
2360690
2360691
2360692
2360693
2360694
2360695
2360696
2360697
2360699
2360701
2360702
40425_at
7905929
A_14_P133452
A_23_P113005
A_23_P254512
GE57985
GO:0000122
GO:0001525
GO:0001934
GO:0003180
GO:0003183
GO:0003199
GO:0005102
GO:0005515
GO:0005576
GO:0005886
GO:0006355
GO:0007155
GO:0007267
GO:0007411
GO:0010719
GO:0014028
GO:0016020
GO:0016477
GO:0023052
GO:0030154
GO:0030182
GO:0033628
GO:0034446
GO:0043409
GO:0043410
GO:0043535
GO:0045765
GO:0046875
GO:0048013
GO:0048870
GO:0050730
GO:0050731
GO:0050770
GO:0050821
GO:0061002
GO:0061098
GO:0070244
GO:0098552
GO:1902004
GO:1902961
GO:1903051
HMNXSV003006092
ILMN_2371053
ILMN_2371055
M57730_at
PH_hs_0019033
TC01001288.hg
g4758245_3p_at
Participates
as a member of
EFNAs [plasma membrane] (Homo sapiens)
Other forms of this molecule
EFNA1 (19-?) N-ter [extracellular region]
EFNA1(?-182) C-ter [plasma membrane]
Inferred To
efna1b [plasma membrane]
(Danio rerio)
Ephrin [plasma membrane]
(Drosophila melanogaster)
efn-2 [plasma membrane]
(Caenorhabditis elegans)
efna1 [plasma membrane]
(Xenopus tropicalis)
Homologues of EFNA1 [plasma membrane]
(Caenorhabditis elegans)
EFNA1 [plasma membrane]
(Bos taurus)
EFNA1 [plasma membrane]
(Canis familiaris)
EFNA1 [plasma membrane]
(Sus scrofa)
Efna1 [plasma membrane]
(Mus musculus)
Efna1 [plasma membrane]
(Rattus norvegicus)
efn-4 [plasma membrane]
(Caenorhabditis elegans)
efn-3 [plasma membrane]
(Caenorhabditis elegans)
vab-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_872626.1
,
NP_004419.2
ENSEMBL
ENST00000368407
,
ENST00000368406
,
ENSP00000357392
,
ENSP00000357391
OpenTargets
ENSG00000169242
HPA
ENSG00000169242-EFNA1
PRO
P20827
Pharos - Targets
P20827
GlyGen
P20827
PDB
3CZU
,
3MBW
,
3HEI
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