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Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
Stable Identifier
R-HSA-2671873
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Leptin (Homo sapiens)
Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SH2B1 in the LEP:LEPR:JAK2:SH2B1 complex can bind either IRS1 or IRS2 (Duan et al. 2004, Li et al. 2007). The binding brings IRS1/2 into proximity with JAK2 for phosphorylation.
Literature References
PubMed ID
Title
Journal
Year
15316008
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
Duan, C
,
Li, M
,
Rui, L
J Biol Chem
2004
17565041
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms
Li, Z
,
Zhou, Y
,
Carter-Su, C
,
Rui, L
,
Myers, MG
Mol. Endocrinol.
2007
Participants
Input
x 2
IRS1,2 [cytosol]
(Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1 [plasma membrane]
(Homo sapiens)
Output
LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Signaling by Leptin (Homo sapiens)
Inferred From
Phosphorylated Lep:Lepr:Jak2:Sh2b1 Binds Irs1/2 (Mus musculus)
Authored
May, B (2012-11-24)
Reviewed
Scherer, T (2013-08-31)
Gonzalez-Perez, RR (2013-10-26)
Created
May, B (2012-11-26)
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