Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2

Stable Identifier
R-HSA-2671873
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SH2B1 in the LEP:LEPR:JAK2:SH2B1 complex can bind either IRS1 or IRS2 (Duan et al. 2004, Li et al. 2007). The binding brings IRS1/2 into proximity with JAK2 for phosphorylation.

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