The SH2 domain of SH2B1 binds phosphotyrosine-813 of JAK2 (Nishi et al. 2005, Li et al. 2007). Binding of SH2B1 to JAK2 enhances leptin-induced JAK2 activity. SH2B1 also recruits IRS1 for phosphorylation by JAK2 (Li et al. 2007).
Hansen, L, Nishi, M, Shoelson, SE, Werner, ED, Lee, J, Dhe-Paganon, S, Frantz, JD, Oh, BC
Li, Z, Zhou, Y, Carter-Su, C, Rui, L, Myers, MG
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