Phosphorylated LEP:LEPR:JAK2 Binds SH2B1

Stable Identifier
R-HSA-2671872
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
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The SH2 domain of SH2B1 binds phosphotyrosine-813 of JAK2 (Nishi et al. 2005, Li et al. 2007). Binding of SH2B1 to JAK2 enhances leptin-induced JAK2 activity. SH2B1 also recruits IRS1 for phosphorylation by JAK2 (Li et al. 2007).

Literature References
PubMed ID Title Journal Year
15767667 Kinase activation through dimerization by human SH2-B

Hansen, L, Nishi, M, Shoelson, SE, Werner, ED, Lee, J, Dhe-Paganon, S, Frantz, JD, Oh, BC

Mol Cell Biol 2005
17565041 SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms

Li, Z, Zhou, Y, Carter-Su, C, Rui, L, Myers, MG

Mol. Endocrinol. 2007
Participants
Input
Output
Participates
as an event of
Inferred From
Phosphoryated Lep:Lepr:Jak2 Binds Sh2b1 (Mus musculus)
Authored
May, B  (2012-11-24)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-26)
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