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Phosphorylated STAT3 Dissociates from Leptin Receptor
Stable Identifier
R-HSA-2671839
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Leptin (Homo sapiens)
Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated STAT3 dissociates from LEPR in the LEP:LEPR:JAK2 complex, dimerizes, and translocates to the nucleus.
Literature References
PubMed ID
Title
Journal
Year
9405487
Divergent signaling capacities of the long and short isoforms of the leptin receptor
da Silva, B
,
Uotani, S
,
Flier, JS
,
Bjørbaek, C
J. Biol. Chem.
1997
Participants
Input
LEP:p-LEPR:p-JAK2:p-STAT3 [plasma membrane]
(Homo sapiens)
Output
LEP:p-LEPR:p-JAK2 [plasma membrane]
(Homo sapiens)
x 2
p-Y705-STAT3 [cytosol]
(Homo sapiens)
Participates
as an event of
Signaling by Leptin (Homo sapiens)
Inferred From
Phosphorylated Stat3 Dissociates from Leptin Receptor (Mus musculus)
Authored
May, B (2012-11-24)
Reviewed
Scherer, T (2013-08-31)
Gonzalez-Perez, RR (2013-10-26)
Created
May, B (2012-11-26)
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