Phosphorylated LEPR Binds SHP2 (PTPN11)

Stable Identifier
R-HSA-2671747
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated LEPR Binds SHP2 (PTPN11)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SHP2 (PTPN11) interacts with phosphotyrosine-986 of the phosphorylated Leptin receptor (LEPR) (Carpenter et al. 1998). The corresponding site in mouse is phosphotyrosine-985 and in rat phosphotyrosine-986.
SHP2 and SOCS3 compete for the same binding site on LEPR. SHP2 activates MAPK signaling, probably by recruiting GRB2:SOS which activates RAS.
Literature References
PubMed ID Title Journal Year
9600917 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Symes, A, Stahl, N, Farruggella, TJ, Yancopoulos, GD, Carpenter, LR, Karow, ML

Proc. Natl. Acad. Sci. U.S.A. 1998
Participants
Input
Output
Participates
as an event of
Inferred From
Phosphorylated Lepr Binds Shp2 (Mus musculus)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-24)
Cite Us!