NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1

Stable Identifier
R-HSA-2666278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) translocation mutant is susceptible to ADAM10/17-mediated cleavage in the absence of ligand binding (Ellisen et al. 1991).

Literature References
PubMed ID Title Journal Year
1831692 TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Ellisen, LW, Bird, J, West, DC, Soreng, AL, Reynolds, TC, Smith, SD, Sklar, J

Cell 1991
Participants
Participates
Catalyst Activity

metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]

Functional status

Gain of function of NOTCH1 t(7;9)(NOTCH1:M1580 K2555) [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
T-cell leukemia DOID:715
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
Cite Us!