NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1

Stable Identifier
R-HSA-2666278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NOTCH1 t(7;9)(NOTCH1:M1580_K2555) translocation mutant is susceptible to ADAM10/17-mediated cleavage in the absence of ligand binding (Ellisen et al. 1991).

Literature References
PubMed ID Title Journal Year
1831692 TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Ellisen, LW, Bird, J, West, DC, Soreng, AL, Reynolds, TC, Smith, SD, Sklar, J

Cell 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created