Reactome | CETP-mediated lipid exchange: spherical HDL gains triacylglycerol

CETP-mediated lipid exchange: spherical HDL gains triacylglycerol

Stable Identifier

R-HSA-266328

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol

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CETP-mediated lipid exchange: spherical HDL gains triacylglycerol

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CETP (cholesterol ester transfer protein) complexed with triacylglycerol interacts with a spherical HDL (high density lipoprotein) particle, acquiring cholesterol ester molecules and donating triacylglycerol to the HDL (Swenson et al. 1988; Morton and Zilversmit 1983). This process is reversible but in the body proceeds in the direction annotated here. A model for the lipid exchange process has been proposed based on recent studies of the structure of CETP:lipid complexes (Qiu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
6619141	Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma Zilversmit, DB, Morton, RE	J Biol Chem	1983
2833496	Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids Brocia, RW, Swenson, TL, Tall, AR	J Biol Chem	1988
17237796	Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules Danley, DE, Hoth, LR, Mistry, A, Culp, JS, Ammirati, MJ, Griffor, MC, McGrath, KM, Zhao, H, Wang, IK, Qiu, X, Subashi, AK, Seddon, AP, Freeman, TB, Karam, GA, Hawrylik, SJ, Lloyd, DB, Subashi, TA, Clark, RW, Stutzman-Engwall, KJ, Chrunyk, BA, Cong, Y, Hensley, P, Lira, ME, Hayward, CM, Thompson, JF, Geoghegan, KF	Nat Struct Mol Biol	2007