CETP-mediated lipid exchange: spherical HDL gains triacylglycerol

Stable Identifier
Reaction [transition]
Homo sapiens
CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol
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CETP (cholesterol ester transfer protein) complexed with triacylglycerol interacts with a spherical HDL (high density lipoprotein) particle, acquiring cholesterol ester molecules and donating triacylglycerol to the HDL (Swenson et al. 1988; Morton and Zilversmit 1983). This process is reversible but in the body proceeds in the direction annotated here. A model for the lipid exchange process has been proposed based on recent studies of the structure of CETP:lipid complexes (Qiu et al. 2007).

Literature References
PubMed ID Title Journal Year
6619141 Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma

Zilversmit, DB, Morton, RE

J Biol Chem 1983
2833496 Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids

Brocia, RW, Swenson, TL, Tall, AR

J Biol Chem 1988
17237796 Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules

Danley, DE, Hoth, LR, Mistry, A, Culp, JS, Ammirati, MJ, Griffor, MC, McGrath, KM, Zhao, H, Wang, IK, Qiu, X, Subashi, AK, Seddon, AP, Freeman, TB, Karam, GA, Hawrylik, SJ, Lloyd, DB, Subashi, TA, Clark, RW, Stutzman-Engwall, KJ, Chrunyk, BA, Cong, Y, Hensley, P, Lira, ME, Hayward, CM, Thompson, JF, Geoghegan, KF

Nat Struct Mol Biol 2007
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