CETP-mediated lipid exchange: spherical HDL gains triacylglycerol

Stable Identifier
R-HSA-266328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CETP (cholesterol ester transfer protein) complexed with triacylglycerol interacts with a spherical HDL (high density lipoprotein) particle, acquiring cholesterol ester molecules and donating triacylglycerol to the HDL (Swenson et al. 1988; Morton and Zilversmit 1983). This process is reversible but in the body proceeds in the direction annotated here. A model for the lipid exchange process has been proposed based on recent studies of the structure of CETP:lipid complexes (Qiu et al. 2007).

Literature References
PubMed ID Title Journal Year
2833496 Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids

Swenson, TL, Brocia, RW, Tall, AR

J Biol Chem 1988
6619141 Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma

Morton, RE, Zilversmit, DB

J Biol Chem 1983
17237796 Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules

Qiu, X, Mistry, A, Ammirati, MJ, Chrunyk, BA, Clark, RW, Cong, Y, Culp, JS, Danley, DE, Freeman, TB, Geoghegan, KF, Griffor, MC, Hawrylik, SJ, Hayward, CM, Hensley, P, Hoth, LR, Karam, GA, Lira, ME, Lloyd, DB, McGrath, KM, Stutzman-Engwall, KJ, Subashi, AK, Subashi, TA, Thompson, JF, Wang, IK, Zhao, H, Seddon, AP

Nat Struct Mol Biol 2007
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created