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Spherical HDL binds C and E apolipoproteins
Stable Identifier
R-HSA-266303
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
HDL remodeling (Homo sapiens)
Spherical HDL binds C and E apolipoproteins (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Spherical HDL particles can bind apoC-II, apoC-III and and apoE proteins. The sources of these proteins and their role or roles in HDL function under physiological conditions are not well understood, however (Kontush and Chapman 2006).
Literature References
PubMed ID
Title
Journal
Year
16968945
Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
Chapman, MJ
,
Kontush, A
Pharmacol Rev
2006
Participants
Input
APOC2 [extracellular region]
(Homo sapiens)
APOC3 [extracellular region]
(Homo sapiens)
APOE [extracellular region]
(Homo sapiens)
spherical HDL [extracellular region]
(Homo sapiens)
Output
spherical HDL:apoC-II:apoC-III:apoE [extracellular region]
(Homo sapiens)
Participates
as an event of
HDL remodeling (Homo sapiens)
Orthologous Events
Spherical HDL binds C and E apolipoproteins (Bos taurus)
Spherical HDL binds C and E apolipoproteins (Canis familiaris)
Spherical HDL binds C and E apolipoproteins (Mus musculus)
Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)
Spherical HDL binds C and E apolipoproteins (Sus scrofa)
Authored
D'Eustachio, P (2008-05-12)
Reviewed
Jassal, B (2008-06-13)
Created
D'Eustachio, P (2008-05-05)
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