NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1

Stable Identifier
R-HSA-2660822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant, which results from fusion of NOTCH1 intron 24 with the promoter of T-cell receptor TCRB, lacks extracellular EGF repeats involved in ligand binding and is not able to bind JAG1 (Ellisen et al. 1991).

Literature References
PubMed ID Title Journal Year
1831692 TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Ellisen, LW, Bird, J, West, DC, Soreng, AL, Reynolds, TC, Smith, SD, Sklar, J

Cell 1991
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created