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LTA4H [cytosol]
Stable Identifier
R-HSA-266022
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Leukotriene A-4 hydrolase-1, LKHA4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of D-series resolvins (Homo sapiens)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
Biosynthesis of aspirin-triggered D-series resolvins (Homo sapiens)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
Biosynthesis of protectins (Homo sapiens)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
Biosynthesis of EPA-derived SPMs (Homo sapiens)
Biosynthesis of E-series 18(R)-resolvins (Homo sapiens)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
Biosynthesis of E-series 18(S)-resolvins (Homo sapiens)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
LTA4 is hydolysed to LTB4 by LTA4H (Homo sapiens)
LTA4H:Zn2+ [cytosol] (Homo sapiens)
LTA4H [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09960 LTA4H
Gene Names
LTA4H, LTA4
Chain
initiator methionine:, chain:2-611
Reference Genes
BioGPS Gene:4048 LTA4H
COSMIC (genes):LTA4H LTA4H
CTD Gene:4048 LTA4H
dbSNP Gene:4048 LTA4H
ENSEMBL:ENSG00000111144 LTA4H
HGNC:6710 LTA4H
KEGG:hsa:4048 LTA4H
Monarch:4048 LTA4H
NCBI Gene:4048 LTA4H
OMIM:151570 LTA4H
UCSC:P09960 LTA4H
Reference Transcript
RefSeq:NM_001256644.1 LTA4H
RefSeq:XM_005268871.1 LTA4H
RefSeq:NM_000895.2 LTA4H
RefSeq:NM_001256643.1 LTA4H
Other Identifiers
11747000_a_at
16768821
208771_PM_s_at
208771_s_at
3466741
3466742
3466743
3466744
3466745
3466746
3466747
3466748
3466749
3466750
3466752
3466756
3466757
3466758
3466759
3466760
3466761
3466762
3466763
3466764
3466765
3466766
3466767
3466768
3466769
3466770
3466771
3466772
3466773
3466774
3466775
3466777
3466778
3466779
38081_at
4048
7965627
A_23_P388670
A_33_P3410093
GE57482
GE86502
GO:0003723
GO:0003824
GO:0004177
GO:0004301
GO:0004463
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006508
GO:0006629
GO:0006691
GO:0008233
GO:0008237
GO:0008270
GO:0010043
GO:0016787
GO:0019370
GO:0019538
GO:0030154
GO:0043171
GO:0043226
GO:0043434
GO:0045148
GO:0046872
GO:0060509
GO:0070006
GO:0070062
GO:0140096
GO:1904724
GO:1904813
HMNXSV003005795
ILMN_1690342
J03459_at
PH_hs_0027166
TC12001843.hg
g187174_3p_a_at
Participates
as a component of
LTA4H:Zn2+ [cytosol] (Homo sapiens)
Other forms of this molecule
LTA4H [tertiary granule lumen]
LTA4H [extracellular region]
LTA4H [ficolin-1-rich granule lumen]
Inferred To
LTA4H [cytosol]
(Bos taurus)
LTA4H [cytosol]
(Caenorhabditis elegans)
LTA4H [cytosol]
(Canis familiaris)
LTA4H [cytosol]
(Danio rerio)
LTA4H [cytosol]
(Dictyostelium discoideum)
LTA4H [cytosol]
(Drosophila melanogaster)
LTA4H [cytosol]
(Gallus gallus)
LTA4H [cytosol]
(Mus musculus)
LTA4H [cytosol]
(Rattus norvegicus)
LTA4H [cytosol]
(Saccharomyces cerevisiae)
LTA4H [cytosol]
(Schizosaccharomyces pombe)
LTA4H [cytosol]
(Sus scrofa)
LTA4H [cytosol]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
LKHA4_HUMAN
Guide to Pharmacology - Targets
1395
OpenTargets
ENSG00000111144
ENSEMBL
ENSP00000395051
,
ENST00000413268
,
ENST00000228740
,
ENST00000552789
,
ENSP00000449958
,
ENSP00000228740
ZINC - FDA approved
LKHA4_HUMAN
ZINC - Substances
LKHA4_HUMAN
ZINC - Biogenic
LKHA4_HUMAN
ZINC target
P09960
PRO
P09960
GlyGen
P09960
PDB
3FU0
,
3FTW
,
5NI4
,
3B7T
,
3FTU
,
4RSY
,
7LLQ
,
4R7L
,
5NID
,
4MS6
,
7AUZ
,
1HS6
,
2VJ8
,
5NI6
,
1H19
,
3U9W
,
3FUJ
,
8RX9
,
3FUE
,
3CHR
,
5FWQ
,
4MKT
,
5BPP
,
4L2L
,
3CHP
,
3FUL
,
3FUI
,
3FH5
,
3CHO
,
6ENC
,
3FUN
,
3FUF
,
5AEN
,
8RX7
,
3FTY
,
3FH8
,
3B7S
,
3FU5
,
8QQ4
,
3FU3
,
3FTV
,
7AV0
,
5NIA
,
7AV1
,
3FU6
,
2R59
,
3FTZ
,
5NI2
,
3B7U
,
5NIE
,
8AWH
,
3FTX
,
7AV2
,
4DPR
,
7KZE
,
8QOW
,
8AVA
,
3FUM
,
6ENB
,
1GW6
,
3FUD
,
3FUK
,
4RVB
,
3CHQ
,
5N3W
,
3FUH
,
6END
,
6O5H
,
3CHS
,
8RX3
,
3B7R
,
3FTS
,
8QPN
,
1SQM
,
3FHE
,
3FH7
ZINC - Investigational
LKHA4_HUMAN
ZINC - Metabolites
LKHA4_HUMAN
HPA
ENSG00000111144-LTA4H
Pharos - Targets
P09960
ZINC - Predictions - Purchasable
LKHA4_HUMAN
HMDB Protein
HMDBP01015
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