Reactome | THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1

THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1

Stable Identifier

R-HSA-265429

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1

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The alpha3beta1 integrin is localized in cell-cell junctions of endothelial cells and this integrin is involved in regulating angiogenesis by interacting with thrombospondin-1 (TSP1). Alpha4beta1 integrin binds to the N-terminal pentraxin modules of TSP1 and stimulates chemotaxis and modulates T cell behavior both positively and negatively.

Literature References

PubMed ID	Title	Journal	Year
10982388	Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1 Chandrasekaran, L, He, CZ, Al-Barazi, H, Krutzsch, HC, Iruela-Arispe, ML, Roberts, DD	Mol Biol Cell	2000
11980922	Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior Li, Z, Calzada, MJ, Sipes, JM, Cashel, JA, Krutzsch, HC, Annis, DS, Mosher, DF, Roberts, DD	J Cell Biol	2002