Reactome | Interaction of integrin alphaVbeta3 with Tenascin

Interaction of integrin alphaVbeta3 with Tenascin

Stable Identifier

R-HSA-265426

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interaction of integrin alphaVbeta3 with Tenascin

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Tenascin, an extracellular matrix protein acts as a ligand to multiple integrin receptors including alphaVbeta3. Integrin alphaVbeta3 binds to the third fibronectin type III repeat in tenascin (Tnfn3) and induces the cell proliferation.

Literature References

PubMed ID	Title	Journal	Year
8798654	Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains Monis, H, Yokosaki, Y, Sheppard, D, Chen, J	J Biol Chem	1996