Reactome | Interaction of integrin alphaVbeta3 with Fibrillin

Interaction of integrin alphaVbeta3 with Fibrillin

Stable Identifier

R-HSA-265423

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interaction of integrin alphaVbeta3 with Fibrillin

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Fibrillins are the main constituents of the extracellular microfibrils that form a template for tropoelastin during elastic fibrillogenesis. Fibrillins polymerize extracellularly as parallel bundles of head-to-tail monomers. The integrin receptor alphaVbeta3 is the major receptor for the fibrillin ligands and influences cell shape and migration, focal complex formation, signaling and ECM deposition.

Literature References

PubMed ID	Title	Journal	Year
12807887	Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins Bax, DV, Bernard, SE, Lomas, A, Morgan, A, Humphries, J, Shuttleworth, CA, Humphries, MJ, Kielty, CM	J Biol Chem	2003