Fibrillins are the main constituents of the extracellular microfibrils that form a template for tropoelastin during elastic fibrillogenesis. Fibrillins polymerize extracellularly as parallel bundles of head-to-tail monomers. The integrin receptor alphaVbeta3 is the major receptor for the fibrillin ligands and influences cell shape and migration, focal complex formation, signaling and ECM deposition.
Humphries, MJ, Lomas, A, Kielty, CM, Humphries, J, Shuttleworth, CA, Bax, DV, Bernard, SE, Morgan, A
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