Reactome | PTGES3 [cytosol]

PTGES3 [cytosol]

Stable Identifier

R-HSA-265269

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Prostaglandin E synthase 3, cPGES

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Locations in the PathwayBrowser for interactor UniProt:Q02790 FKBP4

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External Reference Information

External Reference

UniProt:Q15185 PTGES3

Gene Names

PTGES3, P23, TEBP

Chain

chain:1-160

Reference Genes

BioGPS Gene:10728 PTGES3

COSMIC (genes):PTGES3 PTGES3

CTD Gene:10728 PTGES3

dbSNP Gene:10728 PTGES3

ENSEMBL:ENSG00000110958 PTGES3

HGNC:16049 PTGES3

KEGG:hsa:10728 PTGES3

Monarch:10728 PTGES3

NCBI Gene:10728 PTGES3

OMIM:607061 PTGES3

UCSC:Q15185 PTGES3

Reference Transcript

Other Identifiers

10728

11743372_s_at

11747662_x_at

11751818_x_at

11753366_x_at

16766283

200627_PM_at

200627_at

2421920

2421921

2473546

2793347

3163060

32548_at

3261927

3458058

3458059

3458060

3458061

3458064

3458065

3458070

3458073

3458076

3458078

3458086

3458088

3458089

3458090

3458091

3458092

7964250

GE79257

GO:0000723

GO:0000781

GO:0001516

GO:0003720

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005697

GO:0005737

GO:0005829

GO:0005975

GO:0005978

GO:0006091

GO:0006457

GO:0006629

GO:0007004

GO:0007165

GO:0016740

GO:0016853

GO:0019371

GO:0032200

GO:0032212

GO:0032991

GO:0042921

GO:0043226

GO:0043588

GO:0048144

GO:0048856

GO:0050220

GO:0050821

GO:0051082

GO:0051085

GO:0051087

GO:0051131

GO:0051879

GO:0060430

GO:0065003

GO:0070182

GO:0101031

GO:0140097

GO:1905323

HMNXSV003016817

HMNXSV003057078

ILMN_1719749

L24804_at

PH_hs_0040316

TC12001612.hg

TC12002910.hg

g12804292_3p_at

g12804292_3p_x_at

Participates

as a member of

PTGES2(88-377), PTGES3 [cytosol] (Homo sapiens)

as a component of

as an input of

as an output of

Other forms of this molecule

PTGES3 [nucleoplasm]

Inferred To

Ghost homologue of PTGES3 [cytosol] (Canis familiaris)

Ptges3 [cytosol] (Mus musculus)

Ptges3 [cytosol] (Rattus norvegicus)

SBA1 [cytosol] (Saccharomyces cerevisiae)

daf-41 [cytosol] (Caenorhabditis elegans)

PTGES3 [cytosol] (Bos taurus)

PTGES3 [cytosol] (Dictyostelium discoideum)

PTGES3 [cytosol] (Gallus gallus)

PTGES3 [cytosol] (Plasmodium falciparum)

PTGES3 [cytosol] (Sus scrofa)

p23 [cytosol] (Drosophila melanogaster)

ptges3a [cytosol] (Danio rerio)

wos2 [cytosol] (Schizosaccharomyces pombe)

ptges3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_006592.3, NP_001269534.1, NP_001269533.1, NP_001269532.1, NP_001269531.1, NP_001269530.1

Guide to Pharmacology - Targets

1379

OpenTargets

ENSG00000110958

ENSEMBL

ENST00000262033, ENST00000448157, ENST00000414274, ENST00000436399, ENSP00000405299, ENSP00000402385, ENSP00000262033, ENSP00000414892

HPA

ENSG00000110958-PTGES3

PRO

Q15185

Pharos - Targets

Q15185

GlyGen

Q15185

HMDB Protein

HMDBP10674

PDB

1EJF, 7L7I, 7KRJ, 7L7J

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.857	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.847	7
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.725	4
UniProt:Q9NRG4 SMYD2	1	SMYD2 [nucleoplasm] (R-HSA-3222233)	0.669	3
UniProt:O14802 POLR3A	2	POLR3A [cytosol] (R-HSA-1964433) POLR3A [nucleoplasm] (R-HSA-83700)	0.669	3
UniProt:O94763 RMP			0.669	3
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.643	5
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.643	4
UniProt:Q9Y463 DYR1B			0.643	3
UniProt:Q14190 SIM2			0.573	2
UniProt:Q8NI77 KIF18A	1	KIF18A [cytosol] (R-HSA-376239)	0.527	3
UniProt:Q9NZ71 RTEL1	2	RTEL1 [cytosol] (R-HSA-2564769) RTEL1 [nucleoplasm] (R-HSA-5686112)	0.527	2
UniProt:O00170 AIP	2	AIP [nucleoplasm] (R-HSA-8937156) AIP [cytosol] (R-HSA-8936839)	0.527	2
UniProt:Q8TAT5 NEIL3	2	NEIL3 [nucleoplasm] (R-HSA-9629184) NEIL3 D132V [nucleoplasm] (R-HSA-9629268)	0.527	3
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.527	2
UniProt:P51530 DNA2	1	DNA2 [nucleoplasm] (R-HSA-68465)	0.527	2
UniProt:O95248 SBF1	2	SBF1 [cytosol] (R-HSA-8876843) SBF1 [endoplasmic reticulum membrane] (R-HSA-6809747)	0.527	2
UniProt:Q709F0 ACAD11	1	ACAD11 [mitochondrial inner membrane] (R-HSA-5695987)	0.527	2
UniProt:Q9HBG6 IFT122	2	IFT122 [cilium] (R-HSA-5610379) IFT122 [ciliary tip] (R-HSA-5625346)	0.527	3
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.527	2
UniProt:Q96JG8 MAGD4			0.527	2
UniProt:Q9Y312 AAR2			0.527	2
UniProt:Q9NWK9 BCD1			0.527	2
UniProt:Q9NUG6 PDRG1			0.527	2
UniProt:Q9GZT9 EGLN1	1	EGLN1 [cytosol] (R-HSA-1234108)	0.527	3
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.527	3
UniProt:P51957 NEK4			0.527	2
UniProt:Q07864 POLE	1	POLE [nucleoplasm] (R-HSA-68473)	0.527	3
UniProt:Q96EK5 KBP			0.527	3
UniProt:O00522 KRIT1			0.527	2
UniProt:Q5THK1 PR14L			0.527	3
UniProt:Q96IC2 REXO5			0.527	2
UniProt:Q8IV38 ANKY2			0.527	3
UniProt:Q6P1M9 ARMX5			0.527	2
UniProt:Q9UBB6 NCDN			0.527	2
UniProt:Q9P2P1 NYNRI			0.527	2
UniProt:O95905 ECD			0.527	3
UniProt:Q12789 GTF3C1	1	GTF3C1 [nucleoplasm] (R-HSA-83697)	0.527	3
UniProt:Q7Z6J6 FRMD5			0.527	2
UniProt:Q9HCK5 AGO4	1	EIF2C4 [cytosol] (R-HSA-210612)	0.527	3
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.499	3
UniProt:O14654 IRS4	2	p-Y-IRS4 [plasma membrane] (R-HSA-2424302) IRS4 [plasma membrane] (R-HSA-2424297)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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