Insulin secretory granule translocates to cell cortex

Stable Identifier
R-HSA-265160
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Insulin secretory granule translocates to cell cortex
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Insulin-containing secretory vesicles are translocated along microtubules (polymerized tubulin) from the trans-golgi to the cellular cortex. Motor activity is provided by Dynamin-1 but the complex that connects the secretory granule to the Kinesin-1 is not yet fully known. The process is stimulated by intracellular calcium ions (Ca2+).
Literature References
PubMed ID Title Journal Year
16714477 Insulin vesicle release: walk, kiss, pause ... then run

Rutter, GA, Hill, EV

Physiology (Bethesda) 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

microtubule motor activity of KIF5B-like proteins [cytosol]

Physical Entity
KIF5B-like proteins [cytosol] (Homo sapiens)
Activity
microtubule motor activity (GO:0003777)
Inferred From
Insulin secretory granule translocates to cell cortex (Mus musculus)
Authored
May, B  (2008-05-13)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
May, B  (2008-04-15)
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