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PCSK2 [secretory granule lumen]
Stable Identifier
R-HSA-265156
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
PC2, Prohormone Convertase2
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Insulin processing (Homo sapiens)
PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)
PCSK2 [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16519 PCSK2
Gene Names
PCSK2, NEC2
Chain
signal peptide:1-25, propeptide:26-109, chain:110-638
Reference Genes
BioGPS Gene:5126 PCSK2
COSMIC (genes):PCSK2 PCSK2
CTD Gene:5126 PCSK2
dbSNP Gene:5126 PCSK2
ENSEMBL:ENSG00000125851 PCSK2
HGNC:8744 PCSK2
Monarch:5126 PCSK2
NCBI Gene:5126 PCSK2
OMIM:162151 PCSK2
UCSC:P16519 PCSK2
Reference Transcript
RefSeq:NM_001201529.2 PCSK2
RefSeq:NM_002594.4 PCSK2
RefSeq:NM_001201528.1 PCSK2
Other Identifiers
11736921_a_at
11736922_s_at
16911632
204869_PM_at
204869_at
204870_PM_s_at
204870_s_at
3877893
3877894
3877895
3877896
3877897
3877899
3877900
3877908
3877909
3877950
3877952
3877954
3877964
3877968
3877970
3877974
3877975
3877976
3877982
3877983
3877989
3877990
3877991
3877992
3877993
3877994
41020_at
46562_at
5126
8061094
80774_r_at
A_14_P118766
A_23_P79968
GE62506
GO:0003824
GO:0004175
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005654
GO:0006508
GO:0007399
GO:0008236
GO:0016020
GO:0016485
GO:0016486
GO:0016540
GO:0016787
GO:0030070
GO:0030133
GO:0030141
GO:0030425
GO:0031410
GO:0034230
GO:0034231
GO:0043005
GO:0043025
GO:0043204
GO:0043226
GO:0043231
GO:0048856
GO:0051604
GO:0140096
HMNXSV003042526
Hs.93164.0.S2_3p_at
ILMN_1695003
J05252_s_at
PH_hs_0023758
TC20000108.hg
g4505646_3p_s_at
Cross References
Guide to Pharmacology - Targets
2383
ENSEMBL
ENST00000262545
,
ENST00000536609
,
ENSP00000262545
,
ENST00000377899
,
ENSP00000367131
,
ENSP00000437458
OpenTargets
ENSG00000125851
IntEnz
3.4.21.94
HPA
ENSG00000125851-PCSK2
ZINC - Substances
NEC2_HUMAN
ZINC target
P16519
PRO
P16519
Pharos - Targets
P16519
ZINC - Predictions - Purchasable
NEC2_HUMAN
HMDB Protein
HMDBP13578
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96IK1-2 Q96IK12
0.556
3
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