Reactome | Proinsulin:Zinc:Calcium complex translocates to immature secretory granule

Proinsulin:Zinc:Calcium complex translocates to immature secretory granule

Stable Identifier

R-HSA-265153

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

Golgi-associated vesicle

ReviewStatus

5/5

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Proinsulin:Zinc:Calcium complex translocates to immature secretory granule

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Immature, clathrin-coated vesicles containing proinsulin-zinc-calcium complexes bud from the trans-golgi network (Dodson & Steiner 1998; Orsi et al. 1985).

Literature References

PubMed ID	Title	Journal	Year
9631292	The role of assembly in insulin's biosynthesis Dodson, G, Steiner, D	Curr Opin Struct Biol	1998
3896518	Direct identification of prohormone conversion site in insulin-secreting cells Orci, L, Ravazzola, M, Amherdt, M, Madsen, O, Vassalli, JD, Perrelet, A	Cell	1985