Proinsulin translocates from the endoplasmic reticulum to the Golgi

Stable Identifier
R-HSA-265010
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
COPII-coated ER to Golgi transport vesicle
ReviewStatus
5/5
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Proinsulin translocates from the endoplasmic reticulum to the Golgi
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Correctly folded, disulfide-bonded proinsulin in the endoplasmic reticulum moves to the Golgi apparatus via COPII-coated ER to Golgi transport vesicles that bud from the endoplasmic reticulum (Dodson & Steiner 1998; Orci et al. 1985).
Literature References
PubMed ID Title Journal Year
9631292 The role of assembly in insulin's biosynthesis

Steiner, D, Dodson, G

Curr Opin Struct Biol 1998
3896518 Direct identification of prohormone conversion site in insulin-secreting cells

Vassalli, JD, Madsen, O, Amherdt, M, Perrelet, A, Orci, L, Ravazzola, M

Cell 1985
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Authored
May, B  (2008-11-20)
Gopinathrao, G  (2008-11-20)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
May, B  (2008-04-15)
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