Reactome | Proinsulin translocates from the endoplasmic reticulum to the Golgi

Proinsulin translocates from the endoplasmic reticulum to the Golgi

Stable Identifier

R-HSA-265010

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

COPII-coated ER to Golgi transport vesicle

ReviewStatus

5/5

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Proinsulin translocates from the endoplasmic reticulum to the Golgi

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Correctly folded, disulfide-bonded proinsulin in the endoplasmic reticulum moves to the Golgi apparatus via COPII-coated ER to Golgi transport vesicles that bud from the endoplasmic reticulum (Dodson & Steiner 1998; Orci et al. 1985).

Literature References

PubMed ID	Title	Journal	Year
9631292	The role of assembly in insulin's biosynthesis Steiner, D, Dodson, G	Curr Opin Struct Biol	1998
3896518	Direct identification of prohormone conversion site in insulin-secreting cells Vassalli, JD, Madsen, O, Amherdt, M, Perrelet, A, Orci, L, Ravazzola, M	Cell	1985