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Insulin [secretory granule lumen]
Stable Identifier
R-HSA-264998
Type
Complex
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
INS(25-54):INS(90-110)
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Exocytosis of Insulin (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] (Homo sapiens)
Insulin [secretory granule lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Insulin processing (Homo sapiens)
Insulin secretory granule docks at the plasma membrane (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] (Homo sapiens)
Insulin [secretory granule lumen] (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (post actin network) [secretory granule lumen] (Homo sapiens)
Insulin [secretory granule lumen] (Homo sapiens)
Insulin secretory granule translocates across the cortical actin network (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (post actin network) [secretory granule lumen] (Homo sapiens)
Insulin [secretory granule lumen] (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
Insulin [secretory granule lumen] (Homo sapiens)
Insulin secretory granule translocates to cell cortex (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
Insulin [secretory granule lumen] (Homo sapiens)
PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
Insulin [secretory granule lumen] (Homo sapiens)
General
Insulin is composed of the A chain and B chain from proinsulin joined by the following disulfide bonds:
Cys31-Cys96
Cys43-Cys109
Cys95-Cys100
Participants
components
2xHC-INS(25-54) [secretory granule lumen]
(Homo sapiens)
4xHC-INS(90-110) [secretory granule lumen]
(Homo sapiens)
Participates
as a component of
6xInsulin:2xZn2+:Ca2+ (post actin network) [secretory granule lumen] (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] (Homo sapiens)
6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] (Homo sapiens)
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