Reactome | EXOC8 [plasma membrane]

EXOC8 [plasma membrane]

Stable Identifier

R-HSA-264948

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser for interactor UniProt:Q96GS4 BORC6

Expand all

External Reference Information

External Reference

UniProt:Q8IYI6 EXOC8

Gene Names

EXOC8

Chain

chain:1-725

Reference Genes

BioGPS Gene:149371 EXOC8

COSMIC (genes):EXOC8 EXOC8

CTD Gene:149371 EXOC8

dbSNP Gene:149371 EXOC8

ENSEMBL:ENSG00000116903 EXOC8

ENSEMBL_homo_sapiens_GENE:ENSG00000116903.7 EXOC8

HGNC:24659 EXOC8

KEGG Gene (Homo sapiens):149371 EXOC8

Monarch:149371 EXOC8

NCBI Gene:149371 EXOC8

OMIM:615283 EXOC8

UCSC:Q8IYI6 EXOC8

Reference Transcript

RefSeq:NM_175876.4 EXOC8

Other Identifiers

11728131_at

11728132_s_at

149371

16700485

227577_PM_at

227577_at

244502_PM_at

244502_at

2460524

2460525

2460526

2460527

2460528

2460529

2460530

2460531

2460532

2460533

2460534

2460535

2460537

61351_at

7925043

82133_at

A_23_P430161

A_32_P233314

A_33_P3397051

GE506801

GO:0000145

GO:0000278

GO:0000281

GO:0000910

GO:0005515

GO:0005737

GO:0005768

GO:0005770

GO:0005829

GO:0005886

GO:0006887

GO:0006893

GO:0006904

GO:0006914

GO:0007032

GO:0008104

GO:0008289

GO:0015031

GO:0016020

GO:0016192

GO:0016241

GO:0022617

GO:0030198

GO:0030426

GO:0031252

GO:0031267

GO:0031410

GO:0035091

GO:0042995

GO:0043226

GO:0048471

GO:0061024

GO:0090148

GO:0090522

HMNXSV003009959

Hs.120828.0.S1_3p_at

Hs.163222.0.A1_3p_at

ILMN_2083818

PH_hs_0017264

TC01003967.hg

TC01006191.hg

Participates

as a component of

Exocyst Complex [plasma membrane] (Homo sapiens)

as an input of

Exocyst complex formation (Homo sapiens)

Other forms of this molecule

EXOC8 [cytosol]

Inferred To

EXOC8 [plasma membrane] (Bos taurus)

EXOC8 [plasma membrane] (Canis familiaris)

EXOC8 [plasma membrane] (Gallus gallus)

Exoc8 [plasma membrane] (Mus musculus)

Exoc8 [plasma membrane] (Rattus norvegicus)

exoc8 [plasma membrane] (Dictyostelium discoideum)

Exo84 [plasma membrane] (Drosophila melanogaster)

exoc-8 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_787072.2

OpenTargets

ENSG00000116903

GeneCards

Q8IYI6

HPA

ENSG00000116903-EXOC8

Ensembl

ENSP00000355605, ENSG00000116903, ENST00000366645

PRO

Q8IYI6

Pharos - Targets

Q8IYI6

HMDB Protein

HMDBP08387

Interactors (98)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.789	8
UniProt:Q9UKT9 IKZF3			0.781	7
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.725	6
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.725	6
UniProt:P11234 RALB	1	RALB [cytosol] (R-HSA-171015)	0.725	4
UniProt:Q8N6Y0 USBP1			0.703	5
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.666	4
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.666	4
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.638	4
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.638	4
UniProt:Q9Y2D4 EXC6B			0.638	6
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.638	4
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.638	4
UniProt:O76013-2 KRT36			0.601	4
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.599	4
UniProt:Q9H992 MARH7			0.556	3
UniProt:Q969W8 ZNF566	1	ZNF566 [nucleoplasm] (R-HSA-1973878)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:P20807-4 CAPN3			0.556	3
UniProt:Q9BSW7 SYT17			0.556	3
UniProt:Q96GS4 BORC6			0.556	3
UniProt:P15884-3 TCF4			0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
IntAct:EBI-22335676 CCSB ORF ID			0.556	3
UniProt:P0CG20 PRR35			0.556	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.556	5
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.556	3
UniProt:Q9BXY8 BEX2			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q16533 SNAPC1	1	SNAPC1 [nucleoplasm] (R-HSA-83726)	0.556	3
UniProt:Q5T5P2-6 KIAA1217			0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	5
UniProt:Q5EBL2 ZN628			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q6GMQ7 Q6GMQ7			0.556	3
UniProt:Q96GY0 ZC21A			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q01546 KRT76	1	KRT76 [cytosol] (R-HSA-6809633)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q9NZ72 STMN3			0.556	3
UniProt:Q9BRT2 UQCC2	1	UQCC2 [mitochondrial inner membrane] (R-HSA-9865900)	0.556	3
UniProt:Q9Y6H3 ATP23			0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q8N2N9-4 ANKRD36B			0.556	3
UniProt:Q8TDC0 MYOZ3			0.556	3
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.556	5
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:O14777 NDC80	1	NDC80 [cytosol] (R-HSA-375314)	0.556	3
UniProt:A0A1U9X8X8 A0A1U9X8X8			0.556	5
UniProt:P13682 ZNF35			0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q6AI39 BICRL			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q9ULR0-1 Q9ULR01			0.556	3
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.556	3
UniProt:Q96DF8 ESS2			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q7Z3B4 NUP54	2	NUP54 [cytosol] (R-HSA-9634221) NUP54 [nuclear envelope] (R-HSA-157724)	0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.556	5
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q15154-3 PCM1			0.556	3
UniProt:Q9NU19 TB22B			0.556	3
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:Q9NTX9 F217B			0.556	3
UniProt:Q6IC98 GRAM4			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q13360-2 ZNF177			0.556	3
UniProt:Q6QNY1 BL1S2			0.556	3
UniProt:Q99081-3 TCF12			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q6ZMJ2-2 SCARA5			0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q8NAM6 ZSCAN4	1	ZSCAN4 [nucleoplasm] (R-HSA-9816447)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:A8K0Z3 WASH1			0.553	3
UniProt:Q9NX40 OCAD1			0.527	3
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:Q9Y3L3 SH3BP1	1	SH3BP1 [cytosol] (R-HSA-3006458)	0.527	3
UniProt:Q9H4M9 EHD1	1	EHD1 [endosome membrane] (R-HSA-1011616)	0.527	2
UniProt:Q9H223 EHD4			0.527	2
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.527	4
UniProt:O14975 SLC27A2	5	SLC27A2 [cytosol] (R-HSA-9033090) SLC27A2 [plasma membrane] (R-HSA-6806316) SLC27A2 [specific granule membrane] (R-HSA-6799565) SLC27A2 [endoplasmic reticulum membrane] (R-HSA-193386) SLC27A2 [peroxisomal membrane] (R-HSA-389579)	0.527	3
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.527	2
UniProt:Q8TBN0 RAB3IL1	1	RAB3IL1 [cytosol] (R-HSA-8875296)	0.488	2
UniProt:Q5JST6 EFHC2			0.488	2
UniProt:Q9NS73 MBIP	1	MBIP [nucleoplasm] (R-HSA-3662291)	0.488	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6

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