Caspase-mediated cleavage of Lamin B1

Stable Identifier
R-HSA-264871
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, nuclear envelope
ReviewStatus
5/5
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Caspase-mediated cleavage of Lamin B1
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Caspases initiate the destruction of the nucleus cleavage of lamins leads to disassembly of the nuclear lamina. Lamin B is cleaved by active caspase 6 (Orth et al., 1996) (Rao et al., 1996).

Literature References
PubMed ID Title Journal Year
8978814 Lamin proteolysis facilitates nuclear events during apoptosis

Perez, D, Rao, L, White, E

J Cell Biol 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]

Physical Entity
active caspase-6 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of Lamin B1 (Bos taurus)
Caspase-mediated cleavage of Lamin B1 (Canis familiaris)
Caspase-mediated cleavage of Lamin B1 (Danio rerio)
Caspase-mediated cleavage of Lamin B1 (Drosophila melanogaster)
Caspase-mediated cleavage of Lamin B1 (Gallus gallus)
Caspase-mediated cleavage of Lamin B1 (Mus musculus)
Caspase-mediated cleavage of Lamin B1 (Rattus norvegicus)
Caspase-mediated cleavage of Lamin B1 (Sus scrofa)
Caspase-mediated cleavage of Lamin B1 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-04-14)
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