Caspase-mediated cleavage of Lamin B1

Stable Identifier
R-HSA-264871
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Caspases initiate the destruction of the nucleus cleavage of lamins leads to disassembly of the nuclear lamina. Lamin B is cleaved by active caspase 6 (Orth et al., 1996) (Rao et al., 1996).

Literature References
PubMed ID Title Journal Year
8978814 Lamin proteolysis facilitates nuclear events during apoptosis

Rao, L, Perez, D, White, E

J Cell Biol 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created